ArticlePloS one2018
Impact of surface topography on biofilm formation by Candida albicans.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Beyond roughness: Lateral surface architecture drives Candida albicans virulence on denture polymers.Dental materials : official publication of the Academy of Dental Materials · 2026Article
- Inhibiting biofilm growth on ammonium salt-functionalized or fluorinated voice prostheses silicone.Applied microbiology and biotechnology · 2026Article
- Catheter mechanoprophylaxis againstMicrobiology (Reading, England) · 2026Article
- Cyclic strain of poly (methyl methacrylate) surfaces triggered the pathogenicity of Candida albicans.Acta biomaterialia · 2023Article
- Microbial Response to Micrometer-Scale Multiaxial Wrinkled Surfaces.ACS applied materials & interfaces · 2022Article
- Bioadhesion on Textured Interfaces in the Human Oral Cavity-An In Situ Study.International journal of molecular sciences · 2022Article
- Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Review
- Inhibitory effects of Lactobacillus casei Shirota against both Candida auris and Candida spp. isolates that cause vulvovaginal candidiasis and are resistant to antifungals.BMC complementary medicine and therapies · 2021Article
- Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices.Biomedicines · 2021Review
- Cell Rupture and Morphogenesis Control of the Dimorphic YeastACS omega · 2021Article
- Mechanism of Candida pathogenesis: revisiting the vital drivers.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Review
- Biofilm Growth Causes Damage to Silicone Voice Prostheses in Patients after Surgical Treatment of Locally Advanced Laryngeal Cancer.Pathogens (Basel, Switzerland) · 2020Article
- Sewer biofilm microbiome and antibiotic resistance genes as function of pipe material, source of microbes, and disinfection: field and laboratory studies.Environmental science : water research & technology · 2020Article
- Submicrometer-Sized Roughness Suppresses Bacteria Adhesion.ACS applied materials & interfaces · 2020Article
- Antibiotic Susceptibility of Escherichia coli Cells during Early-Stage Biofilm Formation.Journal of bacteriology · 2019Article
- Testing Anti-Biofilm Polymeric Surfaces: Where to Start?International journal of molecular sciences · 2019Review
- Fungal-Host Interaction: Curcumin Modulates Proteolytic Enzyme Activity ofInternational journal of dentistry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Candida albicans is a fungal pathogen that causes serious biofilm-based infections. Here we have asked whether surface topography may affect C. albicans biofilm formation. We tested biofilm growth of the prototypical wild-type strain SC5314 on a series of polydimethylsiloxane (PDMS) solids. The surfaces were prepared with monolayer coatings of monodisperse spherical silica particles that were fused together into a film using silica menisci. The surface topography was varied by varying the diameter of the silica particles that were used to form the film. Biofilm formation was observed to be a strong function of particle size. In the particle size range 4.0-8.0 μm, there was much more biofilm than in the size range 0.5-2.0 μm. The behavior of a clinical isolate from a clade separate from SC5314, strain p76067, showed results similar to that of SC5314. Our results suggest that topographic coatings may be a promising approach to reduce C. albicans biofilm infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.