ArticlePLoS biology2018
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers.
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Who cites it
170 citing papers in PubMed, 307 citations in OpenAlex.
- Mapping the transcriptional diversity of calcium signaling in the mouse and human brain.iScience · 2026Article
- Single-nucleus profiling reveals a core disease signature and cell type-specific vulnerabilities in early Rett syndrome.Science advances · 2026Article
- MicNet: integrating spatially resolved transcriptomes and pathology images by contrastive deep neural network.Genome biology · 2026Article
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- Dual platform spatial transcriptomics reveals parvalbumin interneuron subtype vulnerability in mouse models of Alzheimer's disease.Nature communications · 2026Article
- Dendritic Inhibition Terminates Plateau Potentials in CA1 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Resting-state EEG alpha-BOLD coupling spatially follows cortical cell-type and receptor gradients.bioRxiv : the preprint server for biology · 2026Article
- A transcriptomic axis aligns with in vivo functional dynamics in hippocampal inhibitory circuits.bioRxiv : the preprint server for biology · 2026Article
- Visualization and simulation of full-scale point-neuron circuits via the Neural Circuit Visualizer web platform.Scientific reports · 2026Article
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- Sex and life experience shape locus coeruleus pretangle tau pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Disorganized Inhibitory Dynamics in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice.bioRxiv : the preprint server for biology · 2026Article
- Review
- Dendrite-Targeting Inhibitory Interneurons Form Biased Circuits with Deep and Superficial Pyramidal Cells in Hippocampal CA1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping.Nature communications · 2025Article
- Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.Research square · 2025Article
- Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.bioRxiv : the preprint server for biology · 2025Article
- Cortical versus hippocampal network dysfunction in a human brain assembloid model of epilepsy and intellectual disability.Cell reports · 2025Article
- Establishing a continuum of cell types in the visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Cooperative actions of interneuron families support the hippocampal spatial code.Science (New York, N.Y.) · 2025Article
110 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Understanding any brain circuit will require a categorization of its constituent neurons. In hippocampal area CA1, at least 23 classes of GABAergic neuron have been proposed to date. However, this list may be incomplete; additionally, it is unclear whether discrete classes are sufficient to describe the diversity of cortical inhibitory neurons or whether continuous modes of variability are also required. We studied the transcriptomes of 3,663 CA1 inhibitory cells, revealing 10 major GABAergic groups that divided into 49 fine-scale clusters. All previously described and several novel cell classes were identified, with three previously described classes unexpectedly found to be identical. A division into discrete classes, however, was not sufficient to describe the diversity of these cells, as continuous variation also occurred between and within classes. Latent factor analysis revealed that a single continuous variable could predict the expression levels of several genes, which correlated similarly with it across multiple cell types. Analysis of the genes correlating with this variable suggested it reflects a range from metabolically highly active faster-spiking cells that proximally target pyramidal cells to slower-spiking cells targeting distal dendrites or interneurons. These results elucidate the complexity of inhibitory neurons in one of the simplest cortical structures and show that characterizing these cells requires continuous modes of variation as well as discrete cell classes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.