ArticleEmerging infectious diseases2018
Geographically Diverse Clusters of Nontoxigenic Corynebacterium diphtheriae Infection, Germany, 2016-2017.
Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Emerging Corynebacterium diphtheriae ST-212 cluster with truncated tox gene linked by possible sexual transmission.Infection · 2026Article
- Epidemiology and Trends ofOpen forum infectious diseases · 2026Article
- Genomic regulation of the diphtheria toxin gene and Its implications for molecular diagnostics and surveillance in low-resource settings.Molecular biology reports · 2026Review
- Prevalence of diphtheria and antimicrobial-resistant wound infections among asylum seekers in Heidelberg, Germany, August-October 2024.PloS one · 2026Article
- A large number of variants ofPeerJ · 2026Article
- Toxigenic diphtheria rarely detected amid rising cases of nontoxigenicJournal of clinical microbiology · 2025Article
- Two diphtheria sub-clusters with autochthonous cases in Germany and Poland within aEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Autochthonous outbreak of respiratory diphtheria caused byEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Article
- Diphtheria Outbreak among Persons Experiencing Homelessness, 2023, Linked to 2022 Diphtheria Outbreak, Frankfurt am Main, Germany.Emerging infectious diseases · 2025Article
- Corynebacterium diphtheriae Infections, South Africa, 2015-2023.Emerging infectious diseases · 2025Article
- From neglect to necessity: The case for routine work-up of nontoxigenicAfrican journal of laboratory medicine · 2025Article
- Description of two novelbioRxiv : the preprint server for biology · 2024Article
- Cluster of Nontoxigenic Corynebacterium diphtheriae Infective Endocarditis and Rising Background C. diphtheriae Cases-Seattle, Washington, 2020-2023.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Non-toxigenic Corynebacterium diphtheriae cutaneous infections among two injecting drug-users with HIV/Tuberculosis coinfection from Bucharest, Romania.New microbes and new infections · 2024Article
- Genomic characterization of cocirculatingMicrobial genomics · 2023Article
- Clustering of Diphtheria Cases in Refugees That Arrived in Germany in 2022.Deutsches Arzteblatt international · 2023Article
- Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia.Microbiology spectrum · 2023Article
- Genomic Analysis ofInternational journal of molecular sciences · 2023Article
- Outbreak of imported diphtheria withEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
From 2016 through the middle of 2017, the German Consiliary Laboratory on Diphtheria noted an increase in nontoxigenic Corynebacterium diphtheriae isolates submitted from cities in northern Germany. Many patients for whom epidemiologic data were available were homeless, alcohol or drug abusers, or both. After performing routine diagnostics and multilocus sequence typing (MLST), we analyzed isolates of sequence type (ST) 8 and previously submitted isolates by whole-genome sequencing. Results were analyzed for phylogenetic relationship by core genome MLST (cg-MLST) and whole-genome single-nucleotide polymorphism profiles. Next-generation sequencing-based cg-MLST revealed several outbreak clusters caused by ST8; the geographic focus was in the metropolitan areas of Hamburg and Berlin. To achieve enhanced analytical depth, we used additional cg-MLST target genes and genome-wide single-nucleotide polymorphisms. We identified patient characteristics and detected transmission events, providing evidence that nontoxigenic C. diphtheriae infection is a potential public health threat in industrialized countries.
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