ArticleAutophagy2018
ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans.
Article in Autophagy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
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- Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.Translational vision science & technology · 2024Article
- SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans.Development (Cambridge, England) · 2023Article
- Transcriptional Regulation ofMicrobiology spectrum · 2023Article
- Chromatin: the old and young of it.Frontiers in molecular biosciences · 2023Review
- Isoforms of the transcriptional cofactor SIN3 differentially regulate genes necessary for energy metabolism and cell survival.Biochimica et biophysica acta. Molecular cell research · 2022Article
- A brief review of vitamin D as a potential target for the regulation of blood glucose and inflammation in diabetes-associated periodontitis.Molecular and cellular biochemistry · 2022Review
- SIN-3 functions through multi-protein interaction to regulate apoptosis, autophagy, and longevity in Caenorhabditis elegans.Scientific reports · 2022Article
- LncRNA LOC105378097 inhibits cardiac mitophagy in natural ageing mice.Clinical and translational medicine · 2022Article
- Biodegradable reduce expenditure bioreactor for augmented sonodynamic therapy via regulating tumor hypoxia and inducing pro-death autophagy.Journal of nanobiotechnology · 2021Article
- EF24 exerts cytotoxicity against NSCLC via inducing ROS accumulation.Cancer cell international · 2021Article
- Review
- A conserved cysteine-based redox mechanism sustains TFEB/HLH-30 activity under persistent stress.The EMBO journal · 2021Article
- The Molecular Mechanism of Antioxidation of Huolisu Oral Liquid Based on Serum Analysis and Network Analysis.Frontiers in pharmacology · 2021Article
- LncRNA-modulated autophagy in plaque cells: a new paradigm of gene regulation in atherosclerosis?Aging · 2020Review
- The multiple organs insult and compensation mechanism in mice exposed to hypobaric hypoxia.Cell stress & chaperones · 2020Article
- Article
- Iron Oxide Nanoparticles as Autophagy Intervention Agents Suppress Hepatoma Growth by Enhancing Tumoricidal Autophagy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
SIN3, a transcriptional corepressor has been implicated in varied functions both as transcription activator and repressor. Recent studies associated Sin3 with the macroautophagic/autophagic process as a negative regulator of Atg8 and Atg32. Though the role of SIN3 in autophagy is being explored, little is known about the overall effect of SIN3 deletion on the survival of an organism. In this study using a Caenorhabditis elegans sin-3(tm1279);him-5(e1490) strain, we demonstrate that under in vivo conditions SIN-3 differentially modulates autophagy and lifespan. We provide evidence that the enhanced autophagy and decreased lifespan observed in sin-3 deletion mutants is dependent on ROS and intracellular oxidative stress. Inability of the mutant worms to maintain redox balance along with dysregulation of enzymatic antioxidants, depletion of GSH and NADP reserves and elevation of ROS markers compromises the longevity of the worms. It is possible that the enhanced autophagic process observed in sin-3(tm1279);him-5(e1490) worms is required to compensate for oxidative stress generated in these worms. ABBREVIATIONS: cat: catalase; DCFDA: 2',7'-dichlorodihydrofluoroscein diacetate; GSH: reduced glutathione; GSSG: oxidized glutathione; H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.