ArticleJBRA assisted reproduction2018
Morphology vs morphokinetics: a retrospective comparison of inter-observer and intra-observer agreement between embryologists on blastocysts with known implantation outcome.
Article in JBRA assisted reproduction, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Embryologist experience affects concordance with an artificial intelligence embryo ranking algorithm: benefit of artificial intelligence assistance.F&S reports · 2026Article
- Timelapse-based 3D reconstruction of blastocysts reveals 3D morphologies of human blastocysts.NPJ digital medicine · 2025Article
- Accurate machine learning model for human embryo morphokinetic stage detection.Journal of assisted reproduction and genetics · 2025Article
- Rescuing Fertilization Failure in ICSI: A Narrative Review of Calcium Ionophore Activation, PLCζ Testing, and Embryo Morphokinetics.Biomedicines · 2025Review
- Pregnancy and neonatal outcomes of borderline blastocysts: a novel evaluation model based on inner cell mass and trophectoderm parameters.Archives of gynecology and obstetrics · 2025Article
- Laser-assisted hatching is associated with reduced re-expansion of vitrified-thawed blastocysts and has no significant effect on embryo implantation.Journal of ovarian research · 2025Article
- Merging synthetic and real embryo data for advanced AI predictions.Scientific reports · 2025Article
- Article
- Non-invasively predicting euploidy in human blastocysts via quantitative 3D morphology measurement: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2024Article
- Quantifying DNA damage following light sheet and confocal imaging of the mammalian embryo.Scientific reports · 2024Article
- Changes in the transcriptomic profile of cumulus cells under the influence of cumulus-oocytes complex pre-incubation.Scientific reports · 2024Article
- Machine learning in time-lapse imaging to differentiate embryos from young vs old mice†.Biology of reproduction · 2024Article
- Evaluation of the Clinical Efficacy and Trust in AI-Assisted Embryo Ranking: Survey-Based Prospective Study.Journal of medical Internet research · 2024Article
- Abnormal cleavage up to Day 3 does not compromise live birth and neonatal outcomes of embryos that have achieved full blastulation: a retrospective cohort study.Human reproduction (Oxford, England) · 2024Article
- Culture media affect sex after IVF treatment-a detailed analysis of explanatory variables.Journal of assisted reproduction and genetics · 2024Article
- Comparing performance between clinics of an embryo evaluation algorithm based on time-lapse images and machine learning.Journal of assisted reproduction and genetics · 2023Article
- Delineating the heterogeneity of embryo preimplantation development using automated and accurate morphokinetic annotation.Journal of assisted reproduction and genetics · 2023Article
- Inter- and Intra-Observer Agreement Between Embryologists for Cytoplasmic String Assessment in Day 5/6 Human Blastocysts.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- A hybrid artificial intelligence model leverages multi-centric clinical data to improve fetal heart rate pregnancy prediction across time-lapse systems.Human reproduction (Oxford, England) · 2023Article
- TLR-1, TLR-2, and TLR-6 MYD88-dependent signaling pathway: A potential factor in the interaction of high-DNA fragmentation human sperm with fallopian tube epithelial cells.Clinical and experimental reproductive medicine · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOur primary aim was to compare the morphology and morphokinetics on inter- and intra-observer agreement for blastocyst with known implantation outcome. Our secondary aim was to validate the morphokinetic parameters' ability to predict pregnancy using a previous published selection algorithm, and to compare this to standard morphology assessments.
methodsTwo embryologists made independent blinded annotations on two occasions using time-lapse images and morphology evaluations using the Gardner Schoolcraft criteria of 99 blastocysts with known implantation outcome. Inter- and intra-observer agreement was calculated and compared using the two methods. The embryos were grouped based on their morphological score, and on their morphokinetic class using a previous published selection algorithm. The implantation rates for each group was calculated and compared.
resultsThere was moderate agreement for morphology, with agreement on the same embryo score in 55 of 99 cases. The highest agreement rate was found for expansion grade, followed by trophectoderm and inner cell mass. Correlation with pregnancy was inconclusive. For morphokinetics, almost perfect agreement was found for early and late embryo development events, and strong agreement for day-2 and day-3 events. When applying the selection algorithm, the embryo distributions were uneven, and correlation to pregnancy was inconclusive.
conclusionsTime-lapse annotation is consistent and accurate, but our external validation of a previously published selection algorithm was unsuccessful.
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