Evidence map›Paper›PMID 29912520›Full record

ArticleJBRA assisted reproduction2018

Next Generation Sequencing (NGS) in chromosome translocation 46, XX, t (9; X) (q22; q28) - a case report.

Monise Santos, Ivan Henrique Yoshida, Caroline Zulim, Michelli Suemi Tanada, Emerson Barchi Cordts, Caio Parente Barbosa

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JBRA assisted reproduction, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Monise SantosInstituto Ideia Fértil de Saúde Reprodutiva.
Ivan Henrique YoshidaInstituto Ideia Fértil de Saúde Reprodutiva.
Caroline ZulimInstituto Ideia Fértil de Saúde Reprodutiva.
Michelli Suemi TanadaInstituto Ideia Fértil de Saúde Reprodutiva.
Emerson Barchi CordtsInstituto Ideia Fértil de Saúde Reprodutiva.
Caio Parente BarbosaInstituto Ideia Fértil de Saúde Reprodutiva.
Faculdade de Medicina do ABC · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper reports the case of a patient who sought assisted reproductive technology (ART) treatment and was referred to pre-implantation genetic diagnosis (PGD) on account of a chromosomal translocation presented with secondary infertility. The patient underwent a highly complex ART treatment and had 14 metaphase II oocytes collected on the day of follicular aspiration. The embryos were taken to extended culture and five were biopsied and vitrified. The embryo genetic report showed aneuploidy in four of the blastocysts, while the other resulted in 46, XX. In conclusion, chromosome translocations involving the X chromosome might result in the deregulation of gene expression and defective ovarian formation. Therefore, the genes present in the X chromosome are believed to be essential in normal ovarian function.

Indexed as

High-Throughput Nucleotide SequencingPreimplantation DiagnosisTranslocation, GeneticAdultAneuploidyEmbryo TransferFemaleFertilization in VitroGenetic TestingHumansPregnancyassisted human reproductionchromosome translocationNext generation sequencingpre-implantation genetic diagnosis

Identifiers

PMID29912520
PMCPMC6106634
OpenAlexW2886614918

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.