Evidence map›Paper›PMID 29912392›Full record

ArticleNucleic acids research2018

GeneMANIA update 2018.

Max Franz, Harold Rodriguez, Christian Lopes, Khalid Zuberi, Jason Montojo, Gary D Bader, Quaid Morris

Abstract read
In one paragraph

Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 916 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
916citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

916 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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856 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Max FranzThe Donnelly Centre, University of Toronto, Ontario, Canada.
Harold RodriguezThe Donnelly Centre, University of Toronto, Ontario, Canada.
Christian LopesThe Donnelly Centre, University of Toronto, Ontario, Canada.
Khalid ZuberiThe Donnelly Centre, University of Toronto, Ontario, Canada.
Jason MontojoThe Donnelly Centre, University of Toronto, Ontario, Canada.
Gary D BaderThe Donnelly Centre, University of Toronto, Ontario, Canada.
Quaid MorrisThe Donnelly Centre, University of Toronto, Ontario, Canada.

Funding

TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3M
Cytoscape: A Modeling Platform for Biomolecular NetworksR01HG009979 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2017 to 2021
$3.5M
NHGRI NIH HHS R01 HG009979NIGMS NIH HHS P41 GM103504
6 · The paper itself

Abstract

GeneMANIA (http://genemania.org) is a flexible user-friendly web site for generating hypotheses about gene function, analyzing gene lists and prioritizing genes for functional assays. Given a query gene list, GeneMANIA finds functionally similar genes using a wealth of genomics and proteomics data. In this mode, it weights each functional genomic dataset according to its predictive value for the query. Another use of GeneMANIA is gene function prediction. Given a single query gene, GeneMANIA finds genes likely to share function with it based on their interactions with it. Enriched Gene Ontology categories among this set can point to the function of the gene. Nine organisms are currently supported (Arabidopsis thaliana, Caenorhabditis elegans, Danio rerio, Drosophila melanogaster, Escherichia coli, Homo sapiens, Mus musculus, Rattus norvegicus and Saccharomyces cerevisiae). Hundreds of data sets and hundreds of millions of interactions have been collected from GEO, BioGRID, IRefIndex and I2D, as well as organism-specific functional genomics data sets. Users can customize their search by selecting specific data sets to query and by uploading their own data sets to analyze. We have recently updated the user interface to GeneMANIA to make it more intuitive and make more efficient use of visual space. GeneMANIA can now be used effectively on a variety of devices.

Indexed as

Databases, GeneticGenomicsInternetSoftwareAlgorithmsAnimalsArabidopsisDrosophila melanogasterGene OntologyGene Regulatory NetworksHumansMiceRatsSaccharomyces cerevisiaeZebrafish

Identifiers

PMID29912392
PMCPMC6030815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.