ArticleInternational journal of epidemiology2018
A Bayesian approach to investigate life course hypotheses involving continuous exposures.
Article in International journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Total moderate-to-vigorous physical activity across the adult life course and the risk of invasive ovarian cancer.International journal of epidemiology · 2026Article
- The association of childhood HDL cholesterol with atherosclerotic cardiovascular disease events in adults: findings from the International Childhood Cardiovascular Cohort Consortium.European journal of preventive cardiology · 2026Article
- Life-course Psychosocial Adversity and Biological Aging in the Hispanic Community Health Study / Study of Latinos: A Life-course Model Analysis.Research square · 2026Article
- Article
- Socioeconomic status across the early life course predicts gene expression signatures of disease and senescence.Journal of epidemiology and community health · 2024Article
- Body fatness across the adult life course and ovarian cancer risk.European journal of epidemiology · 2024Article
- Article
- Maternal psychological distress and temperament traits in children from infancy to late childhood.JCPP advances · 2024Article
- Cardiovascular Risk Factors in Childhood and Adulthood and Cardiovascular Disease in Middle Age.JAMA network open · 2024Article
- Blood Pressure at Different Life Stages Over the Early Life Course and Intima-Media Thickness.JAMA pediatrics · 2024Article
- A Bayesian functional approach to test models of life course epidemiology over continuous time.International journal of epidemiology · 2024Article
- Incorporating interactions into structured life course modelling approaches: A simulation study and applied example of the role of access to green space and socioeconomic position on cardiometabolic health.medRxiv : the preprint server for health sciences · 2023Article
- An integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research.Discover social science and health · 2023Review
- Applications of conceptual models from lifecourse epidemiology in ecology and evolutionary biology.Biology letters · 2022Review
- Relative Contribution of Blood Pressure in Childhood, Young- and Mid-Adulthood to Large Artery Stiffness in Mid-Adulthood.Journal of the American Heart Association · 2022Article
- Life Course Tobacco Smoking and Risk of HPV-Negative Squamous Cell Carcinomas of Oral Cavity in Two Countries.Frontiers in oral health · 2022Article
- A Bayesian approach to comparing common models of life-course epidemiology.International journal of epidemiology · 2021Article
- Does the timing and duration of mental health problems during childhood and adolescence matter for labour market participation of young adults?Journal of epidemiology and community health · 2021Article
- The Early Life Course of Body Weight and Gene Expression Signatures for Disease.American journal of epidemiology · 2021Article
- A Structured Approach to Evaluating Life-Course Hypotheses: Moving Beyond Analyses of Exposed Versus Unexposed in the -Omics Context.American journal of epidemiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Background: Different hypotheses have been proposed in life course epidemiology on how a time-varying exposure can affect health or disease later in life. Researchers are often interested in investigating the probability of these hypotheses based on observed life course data. However, current techniques based on model/variable selection do not provide a direct estimate of this probability. We propose an alternative technique for a continuous exposure, using a Bayesian approach that has specific advantages, to investigate which life course hypotheses are supported by the observed data. Methods: We demonstrate the technique, the relevant life course exposure model (RLM), using simulations. We also analyse data from a case-control study on risk factors of oral cancer, with repeated measurements of betel quid chewing across life. We investigate the relative importance of chewing one quid of betel per day, at three life periods: ≤20 years, 21-40 years and above 40 years of age, on the risk of developing oral cancer. Results: RLM was able to correctly identify the life course hypothesis under which the data were simulated. Results from the case-control study showed that there was 74.3% probability that betel quid exposure earlier in life, compared with later, results in higher odds of developing oral cancer later in life. Conclusions: RLM is a useful option to identify the life course hypothesis supported by the observed data prior to the estimation of a causal effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.