Evidence map›Paper›PMID 29912151›Full record

ArticleMolecules (Basel, Switzerland)2018

Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge

Aubrie O'Rourke, Stephan Kremb, Brendan M Duggan, Salim Sioud, Najeh Kharbatia, Misjudeen Raji, Abdul-Hamid Emwas, William H Gerwick, Christian R Voolstra

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Bioactive potency of extracts fromBiomedical reports · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aubrie O'RourkeRed Sea Research Center, Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. aubrie.orourke12@gmail.com.
Stephan KrembRed Sea Research Center, Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. sk6225@nyu.edu.
Brendan M DugganScripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. bmduggan@ucsd.edu.ORCID 0000-0002-7034-8374
Salim SioudKing Abdullah University of Science and Technology (KAUST), Core Labs, Thuwal 23955-6900, Saudi Arabia. salim.sioud@kaust.edu.sa.
Najeh KharbatiaKing Abdullah University of Science and Technology (KAUST), Core Labs, Thuwal 23955-6900, Saudi Arabia. najeh.kharbatia@kaust.edu.sa.
Misjudeen RajiKing Abdullah University of Science and Technology (KAUST), Core Labs, Thuwal 23955-6900, Saudi Arabia. rajimi@sheridancollege.ca.
Abdul-Hamid EmwasKing Abdullah University of Science and Technology (KAUST), Core Labs, Thuwal 23955-6900, Saudi Arabia. abdelhamid.emwas@kaust.edu.sa.ORCID 0000-0002-9231-3850
William H GerwickScripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. wgerwick@ucsd.edu.ORCID 0000-0003-1403-4458
Christian R VoolstraRed Sea Research Center, Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. christian.voolstra@kaust.edu.sa.ORCID 0000-0003-4555-3795

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viruses are underrepresented as targets in pharmacological screening efforts, given the difficulties of devising suitable cell-based and biochemical assays. In this study we found that a pre-fractionated organic extract of the Red Sea sponge

Indexed as

AnimalsAntiviral AgentsGas Chromatography-Mass SpectrometryHeLa CellsHumansMagnetic Resonance SpectroscopyModels, MolecularMolecular StructurePoriferaProtease InhibitorsPyridinium CompoundsStructure-Activity RelationshipViral Nonstructural ProteinsWest Nile virusAntiviral AgentsProtease InhibitorsPyridinium CompoundsViral Nonstructural ProteinsantiviralbioprospectinghalitoxinHigh-Content Screening (HCS)NS3 proteaseRed SeaWest Nile Virus

Identifiers

PMID29912151
PMCPMC6099703

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.