ArticleCornea2018
Incidence and Outcomes of Positive Donor Rim Cultures and Infections in the Cornea Preservation Time Study.
Article in Cornea, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Microbiological spectrum and probability of transmission of infection from ocular tissues of enucleated eyes harvested from septicemic donors.World journal of transplantation · 2026Article
- Incidence and management of early postoperative complications in lamellar corneal transplantation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Review
- The Prevalence of Positive Donor Corneoscleral Rim Culture and its Association with Ocular Infection After Transplantation.Beyoglu eye journal · 2023Article
- The impact of amphotericin B-fortified preservation media on donor rim cultures and posttransplant infection.Indian journal of ophthalmology · 2022Article
- Practical Guidance for Clinical Microbiology Laboratories: Diagnosis of Ocular Infections.Clinical microbiology reviews · 2021Review
- First case ofMedical mycology case reports · 2021Article
- Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes.Frontiers in medicine · 2021Review
- Antifungal Efficacy and Safety of Cycloheximide as a Supplement in Optisol-GS.Drug design, development and therapy · 2021Article
- Microorganism detection and contamination rate of donor eyes in Japan.Japanese journal of ophthalmology · 2020Article
- Article
- A presentation of culture-positive corneal donors and the effect on clinical outcomes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Fungal keratitis: Mechanisms of infection and management strategies.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
14 authors at 10 institutions in 1 country.
Funding
Abstract
purposeTo assess donor rim culture results and outcomes of ocular infections in the Cornea Preservation Time Study (CPTS).
methodsDonor corneal rim cultures were optional. Donor characteristics were assessed for association with positive cultures using the Fisher exact test and Poisson regression analyses. Incidence rates of ocular infections were estimated, and 95% confidence intervals were calculated.
resultsCultures were performed in 784 (58.9%) of the 1330 cases. For the 0 to 7-day versus 8 to 14-day preservation time groups, respectively, positive fungal growth occurred in 10 of 397 (2.5%) versus 5 of 387 (1.3%) corneas (P = 0.30), whereas positive bacterial cultures occurred in 6 of 397 (1.5%) versus 4 of 387 (1.0%) corneas (P = 0.75). Surgeon-prepared tissue remained a significant risk for positive fungal cultures [relative risk (RR) of surgeon- versus eye-bank-prepared, 2.85; 95% CI (1.02-7.98)], whereas younger donors [RR per year of age, 0.96; 95% CI (0.93-1.00)] and accidental death donors [RR of accident versus disease, 3.71; 95% CI (1.36-10.13)] were at a greater risk for positive bacterial cultures. Fungal infection (Candida glabrata) developed in 1 (6.7%) of 15 recipients with a positive fungal culture, and no recipient infections occurred with positive bacterial culture. With one additional fungal keratitis (Candida albicans) and one bacterial endophthalmitis (E. coli) with no rim culture performed, a total of 2 of 1330 eyes (0.15%) developed fungal and 1/1330 eyes (0.08%) developed bacterial postkeratoplasty infections.
conclusionsA longer preservation time was not associated with a higher rate of positive donor rim cultures. The overall rate of infection across the entire cohort was low.
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Registered trials
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