ArticleeLife2018
Spatial cell firing during virtual navigation of open arenas by head-restrained mice.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Visual uncertainty and task demands shape active sensing strategies in mice.Current biology : CB · 2026Article
- Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.Annual review of neuroscience · 2026Review
- Voltage imaging of CA1 pyramidal cells and SST+ interneurons reveals stability and plasticity mechanisms of spatial firing.Nature communications · 2026Article
- Visual uncertainty and task demands shape active sensing strategies in mice.bioRxiv : the preprint server for biology · 2026Article
- Coordinated Representational Drift Across the Mouse Cortex.bioRxiv : the preprint server for biology · 2026Article
- Evaluating place cell detection methods in Rats and Humans: Implications for cross-species spatial coding.PLoS computational biology · 2026Article
- A scalable hippocampal code for flexible interval timing through persistent activity.bioRxiv : the preprint server for biology · 2026Article
- Directional dynamics in the entorhinal cortex of male mice driven by behavioral constraints.Nature communications · 2026Article
- Flexible neural representations of abstract structural knowledge in the human entorhinal cortex.eLife · 2026Article
- Review
- Time or distance encoding by hippocampal neurons via heterogeneous ramping rates.Nature communications · 2025Article
- Evaluating Place Cell Detection Methods in Rats and Humans - Implications for Cross-Species Spatial Coding: Place Cell Detection and Cross-Species Spatial Coding.bioRxiv : the preprint server for biology · 2025Article
- Improved spatial memory for physical versus virtual navigation.Journal of neural engineering · 2025Article
- Article
- Article
- MouseGoggles: an immersive virtual reality headset for mouse neuroscience and behavior.Nature methods · 2025Article
- Building egocentric models of local space from retinal input.Current biology : CB · 2024Review
- Early and late place cells during postnatal development of the hippocampus.Nature communications · 2024Article
- The medial entorhinal cortex encodes multisensory spatial information.Cell reports · 2024Article
- Adult zebrafish can learn Morris water maze-like tasks in a two-dimensional virtual reality system.Cell reports methods · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We present a mouse virtual reality (VR) system which restrains head-movements to horizontal rotations, compatible with multi-photon imaging. This system allows expression of the spatial navigation and neuronal firing patterns characteristic of real open arenas (R). Comparing VR to R: place and grid, but not head-direction, cell firing had broader spatial tuning; place, but not grid, cell firing was more directional; theta frequency increased less with running speed, whereas increases in firing rates with running speed and place and grid cells' theta phase precession were similar. These results suggest that the omni-directional place cell firing in R may require local-cues unavailable in VR, and that the scale of grid and place cell firing patterns, and theta frequency, reflect translational motion inferred from both virtual (visual and proprioceptive) and real (vestibular translation and extra-maze) cues. By contrast, firing rates and theta phase precession appear to reflect visual and proprioceptive cues alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.