Evidence map›Paper›PMID 29911175›Full record

ArticleeNeuro

Ethanol Regulates Presynaptic Activity and Sedation through Presynaptic Unc13 Proteins in

Shiyu Xu, Satyabrata Pany, Kevin Benny, Khadeeja Tarique, Ola Al-Hatem, Kathleen Gajewski, J Leigh Leasure, Joydip Das, Gregg Roman

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Single nucleotide variants inBiochemistry and biophysics reports · 2026
    Article
  3. TBI and Tau Loss of Function Both Affect Naïve Ethanol Sensitivity inInternational journal of molecular sciences · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. (M)Unc13s in Active Zone Diversity: AFrontiers in synaptic neuroscience · 2021
    Review
  10. Article
  11. Article
  12. SNARE Complex-Associated Proteins and Alcohol.Alcoholism, clinical and experimental research · 2020
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shiyu XuDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204.
Satyabrata PanyDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204.
Kevin BennyDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204.ORCID 0000-0002-7391-9427
Khadeeja TariqueDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204.
Ola Al-HatemDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204.
Kathleen GajewskiDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204.
J Leigh LeasureBiology of Behavior Institute, University of Houston, Houston, TX 77204.ORCID 0000-0002-9014-2525
Joydip DasDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204.ORCID 0000-0003-1540-5804
Gregg RomanDepartment of Biology, University of Mississippi, MS 38677.ORCID 0000-0003-1519-4699
University of Houston · USUniversity of Mississippi · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Characterization of a novel presynaptic target for ethanol actionR21AA020572 · NIAAA · UNIVERSITY OF HOUSTON · PI DAS, JOYDIP, ROMAN, GREGG W · 2011 to 2012
$394k
NIAAA NIH HHS R21 AA020572NIH HHS P40 OD018537
6 · The paper itself

Abstract

Ethanol has robust effects on presynaptic activity in many neurons, however, it is not yet clear how this drug acts within this compartment to change neural activity, nor the significance of this change on behavior and physiology

Indexed as

AnimalsDrosophilaDrosophila ProteinsEthanolFemaleHypnotics and SedativesMaleMembrane ProteinsNerve Tissue ProteinsNeuronsSynapsesSynaptic VesiclesDrosophila ProteinsEthanolHypnotics and SedativesMembrane ProteinsNerve Tissue ProteinsUnc13a protein, ratunc-13 protein, DrosophilaDrosophilaethanolMunc13-1presynapticresistancetolerance

Identifiers

PMID29911175
PMCPMC6001265
OpenAlexW2806291239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.