ArticleeNeuro
Amygdala Corticofugal Input Shapes Mitral Cell Responses in the Accessory Olfactory Bulb.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Distinct glutamatergic projections of the posteroventral medial amygdala play different roles in arousal and anxiety.JCI insight · 2024Article
- A direction-selective cortico-brainstem pathway adaptively modulates innate behaviors.Nature communications · 2023Article
- A sex-specific feedback projection from aromatase-expressing neurons in the medial amygdala to the accessory olfactory bulb.The Journal of comparative neurology · 2022Article
- Anatomic alterations across amygdala subnuclei in medication-free patients with obsessive-compulsive disorder.Journal of psychiatry & neuroscience : JPN · 2020Article
- Paradoxically Sparse Chemosensory Tuning in Broadly Integrating External Granule Cells in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A different view on the pathophysiology of Parkinson's disease: a descendent neurochemical hypothesis?Neural regeneration research · 2019Article
- Pheromone-Induced Odor Associative Fear Learning in Rats.Scientific reports · 2018Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
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Authors and funding
5 authors.
Funding
Abstract
Interconnections between the olfactory bulb and the amygdala are a major pathway for triggering strong behavioral responses to a variety of odorants. However, while this broad mapping has been established, the patterns of amygdala feedback connectivity and the influence on olfactory circuitry remain unknown. Here, using a combination of neuronal tracing approaches, we dissect the connectivity of a cortical amygdala [posteromedial cortical nucleus (PmCo)] feedback circuit innervating the mouse accessory olfactory bulb. Optogenetic activation of PmCo feedback mainly results in feedforward mitral cell (MC) inhibition through direct excitation of GABAergic granule cells. In addition, LED-driven activity of corticofugal afferents increases the gain of MC responses to olfactory nerve stimulation. Thus, through corticofugal pathways, the PmCo likely regulates primary olfactory and social odor processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.