ArticleTobacco regulatory science2017
Little Cigars vs 3R4F Cigarette: Physical Properties and HPHC Yields.
Article in Tobacco regulatory science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Addiction potential of combustible menthol cigarette alternatives: a randomised cross-over trial.Tobacco control · 2024Trial
- Evaluating the Impact of Little Cigar Use on the Oral Bacterial Microbiota of Cigarette Smokers.Pathogens (Basel, Switzerland) · 2026Article
- Comparison of the 1C2 Reference Filtered Cigar to the 1R6F Reference Filtered Cigarette.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Universal smoking machine adaptor for tobacco product testing.Tobacco control · 2025Article
- Benchmarking a universal smoking machine adaptor for tobacco product testing.Tobacco control · 2025Article
- Benzo[a]pyrene in the Mainstream Smoke of Little Cigars.Chemical research in toxicology · 2025Article
- Comparison of emissions across tobacco products: A slippery slope in tobacco control.Tobacco induced diseases · 2024Review
- Effects of chronic secondhand smoke exposure on cardiovascular regulation and the role of soluble epoxide hydrolase in mice.Frontiers in physiology · 2023Article
- Should IQOS Emissions Be Considered as Smoke and Harmful to Health? A Review of the Chemical Evidence.ACS omega · 2022Review
- Dissonance in Young Adult Cigarillo Users' Categorization of Concept Flavored and Unflavored Products.International journal of environmental research and public health · 2022Article
- TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice.Oncogene · 2022Article
- Nonmedical Cannabis Use: Patterns and Correlates of Use, Exposure, and Harm, and Cancer Risk.Journal of the National Cancer Institute. Monographs · 2021Article
- Volatile Organic Compounds in Mainstream Smoke of Sixty Domestic Little Cigar Products.Chemical research in toxicology · 2021Article
- Secondhand Smoke Decreased Excitability and Altered Action Potential Characteristics of Cardiac Vagal Neurons in Mice.Frontiers in physiology · 2021Article
- Biomarkers of Exposure among U.S. Adult Cigar Smokers: Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Classification of flavors in cigarillos and little cigars and their variable cellular and acellular oxidative and cytotoxic responses.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveOur objective was to characterize physical properties and semivolatile harmful and potentially harmful constituent yields in the mainstream smoke (MSS) of 4 popular little cigars compared to the 3R4F reference cigarette.
methodsWe used the ISO and Canadian Intense Regimen protocols to generate MSS for Cheyenne (Full Flavor and Menthol) and Swisher Sweets (Original and Sweet Cherry) little cigars; and the 3R4F. We examined physical properties such as length, tobacco filler mass, pressure drop, and ventilation for each product. Nicotine, benzo[a]pyrene, and tobacco-specific nitrosamine (TSNA) yields were determined in the MSS.
resultsLittle cigars were longer (~15mm), contained more tobacco filler (100-200 mg), and had a higher pressure drop (~1.3X) compared to the 3R4F. Ventilation holes were found only on the filter paper of the 3R4F. Nicotine transmitted to the MSS was similar for all products under the intense smoking protocol. The highest yields of TSNAs and benzo(a)pyrene were measured for the little cigars.
conclusionsLittle cigars may deliver similar levels of nicotine but higher levels of carcinogens to the MSS compared to cigarettes. Thus, previous reports on the toxicity of tobacco smoke based on cigarettes might not apply to little cigar products.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.