ArticleInternational journal of clinical anesthesiology
Clinical Implications of Bilirubin-Associated Neuroprotection and Neurotoxicity.
Article in International journal of clinical anesthesiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage.Proceedings of the National Academy of Sciences of the United States of America · 2015Trial
- Lab values in neonates with hypoxic ischemic encephalopathy over time during and after therapeutic hypothermia.Frontiers in pediatrics · 2026Article
- Plasma metabonomic study on the effect ofMolecular medicine reports · 2023Article
- Roles of Bilirubin in Hemorrhagic Transformation of Different Types and Severity.Journal of clinical medicine · 2023Article
- Serum bilirubin levels are associated with poor functional outcomes in patients with acute ischemic stroke or transient ischemic attack.BMC neurology · 2021Article
- Monosodium glutamate induces memory and hepatic dysfunctions in mice: ameliorative role of JobelynToxicological research · 2021Article
- Serum bilirubin and ischaemic stroke: a review of literature.Stroke and vascular neurology · 2020Review
- Blood-Related Toxicity after Traumatic Brain Injury: Potential Targets for Neuroprotection.Molecular neurobiology · 2020Review
- Subarachnoid Hemorrhage Increases Level of Heme Oxygenase-1 and Biliverdin Reductase in the Choroid Plexus.Frontiers in cellular neuroscience · 2020Article
- Genetic deletion of the prostaglandin E2 E prostanoid receptor subtype 3 improves anatomical and functional outcomes after intracerebral hemorrhage.The European journal of neuroscience · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Bilirubin is a primary product of heme catabolism and exhibits both neuroprotective and neurotoxic effects. When present at physiologic concentrations, bilirubin is a potent antioxidant and serves to protect brain tissue from oxidative stress insults. The use of the anesthetic propofol attenuates ischemic injury in rats by exploiting these neuroprotective properties. At pathologic levels, bilirubin has been implicated as a neurotoxic agent, demonstrating the ability to aggregate and adhere to cellular membranes, thereby disrupting normal cellular function. Bilirubin-associated toxicities are amplified by administering drugs such as anesthetics that compete with bilirubin for albumin binding sites, resulting in increased plasma bilirubin concentrations. As such, it is crucial that bilirubin is considered in the critical care management of patients with hemorrhagic stroke, cerebral ischemic damage, and critically ill newborns.
Indexed as
Identifiers
29911128PMC5998657W2990759885What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.