Evidence map›Paper›PMID 29911002›Full record

ArticleCurrent opinion in chemical engineering2018

Engineering therapeutic antibodies to combat infectious diseases.

Ellen K Wagner, Jennifer A Maynard

Open access · greenAbstract read
In one paragraph

Article in Current opinion in chemical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Monoclonal Antibody Generation Using Single B Cell Screening for Treating Infectious Diseases.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Medicinal Chemistry of Inhibitors Targeting Resistant Bacteria.Current topics in medicinal chemistry · 2022
    Article
  12. Article
  13. [New aspects of rabies control].Bulletin de l'Academie nationale de medecine · 2020
    Review
  14. Review
  15. New strategies and structural considerations in development of therapeutics for carbapenem-resistant Enterobacteriaceae.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
  16. Article
  17. Article
  18. Article
  19. IgA: Structure, Function, and Developability.Antibodies (Basel, Switzerland) · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ellen K WagnerDepartment of Chemical Engineering, The University of Texas at Austin, Austin TX USA, 78712.
Jennifer A MaynardDepartment of Chemical Engineering, The University of Texas at Austin, Austin TX USA, 78712.
The University of Texas at Austin · US

Funding

Systematic evaluation of B. pertussis ACT’s role as a protective antigenR01AI122753 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI MAYNARD, JENNIFER A · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI122753
6 · The paper itself

Abstract

Serum therapy fell out of favor 80 years ago, but antibodies against infectious diseases are now experiencing a renaissance. With the evolution of antibiotic-resistant bacteria, the emergence of new pathogens, and a growing population of immunocompromised individuals coupled with improvements in antibody manufacturing and biological efficacy, antibodies are an increasingly attractive therapeutic option. In this review, we highlight successful clinical strategies and discuss recent applications of advanced antibody engineering approaches to combat infectious diseases. Case studies include antibody mixtures to neutralize

Identifiers

PMID29911002
PMCPMC5998816
OpenAlexW2792875856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.