Evidence map›Paper›PMID 29910816›Full record

ReviewFrontiers in immunology2018

A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells.

Martin Peter Steinbuck, Susan Winandy

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 96 citations in OpenAlex.

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  19. Impact of the Multiple Sclerosis-Associated Genetic VariantNeurology(R) neuroimmunology & neuroinflammation · 2024
    Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Martin Peter SteinbuckImmunology Training Program, Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, United States.
Susan WinandyImmunology Training Program, Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, United States.
Boston University · US

Funding

Mechanism of Notch-induced leukemogenesis in lymphocytesR21CA176811 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WINANDY, SUSAN M · 2014 to 2015
$404k
NCI NIH HHS R21 CA176811
6 · The paper itself

Abstract

The Notch receptor is an evolutionarily highly conserved transmembrane protein essential to a wide spectrum of cellular systems, and its deregulation has been linked to a vast number of developmental disorders and malignancies. Regulated Notch function is critical for the generation of T-cells, in which abnormal Notch signaling results in leukemia. Notch activation through

Indexed as

Signal TransductionAnimalsCarrier ProteinsEndocytosisHumansLigandsModels, BiologicalProtein BindingProtein TransportReceptors, Antigen, T-CellReceptors, NotchT-LymphocytesCarrier ProteinsLigandsReceptors, Antigen, T-CellReceptors, Notchendocytosisligand-independentNotchprotein kinase CT-cellT-cell receptor

Identifiers

PMID29910816
PMCPMC5992298
OpenAlexW2805217220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.