ReviewFrontiers in immunology2018
The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia.
Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Vasculitis syndromes: the pathogenic roles of COVID-19 and related vaccinations.Virology journal · 2025Review
- Chronic Hepatitis C Virus Infection, Extrahepatic Disease and the Impact of New Direct-Acting Antivirals.Pathogens (Basel, Switzerland) · 2024Review
- Normocomplementemic Urticarial Vasculitis Following Influenza Vaccination: A Case Report and Review of the Literature.International medical case reports journal · 2024Article
- Article
- Serum cystatin C is an early renal dysfunction biomarker in patients with hepatitis C virus.Egyptian liver journal · 2022Article
- Patients with Covid 19 have significantly reduced CH50 activity.Virusdisease · 2021Article
- Interactive Impacts from Hepatitis C Virus Infection and Mixed Cryoglobulinemia on Complement Levels.Digestive diseases and sciences · 2021Article
- Thermal stress-induced oxidative damages in the liver and associated death in fish, Labeo rohita.Fish physiology and biochemistry · 2021Article
- Immunologic markers, vasculitis-associated autoantibodies, and complement levels in patients with COVID-19.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Cryoglobulins: Identification, classification, and novel biomarkers of mysterious proteins.Advances in clinical chemistry · 2021Review
- Urticarial vasculitis in a COVID-19 recovered patient.International journal of dermatology · 2020Article
- The Immunopathology of Complement Proteins and Innate Immunity in Autoimmune Disease.Clinical reviews in allergy & immunology · 2020Review
- In the Crosshairs: RNA Viruses OR Complement?Frontiers in immunology · 2020Review
- The complement system in liver diseases: Evidence-based approach and therapeutic options.Journal of translational autoimmunity · 2019Review
- Understanding the Cryoglobulinemias.Current rheumatology reports · 2019Review
- HCV-Associated Nephropathies in the Era of Direct Acting Antiviral Agents.Frontiers in medicine · 2019Review
- Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis.Journal of immunology research · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complement system bridges innate and adaptive immunity against microbial infections, with viral infection being a major trigger. Activation of the classical, alternative, and lectin pathways have been reported in chronic hepatitis C virus (HCV) infection and/or cryoglobulinemia. HCV infection leads to dysregulation of complement-mediated immune responses. Clinical and experimental evidence support involvement of complement in intra- and extrahepatic manifestations of HCV infection, such as liver fibrosis and type II cryoglobulinemia. In this review, we summarize studies that have investigated the interplay between HCV and the complement system to establish chronic infection and autoimmunity, as well as the association between HCV pathogenesis and abnormal complement profiles. Several unanswered questions are highlighted which suggest additional informative lines of investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.