Evidence map›Paper›PMID 29910740›Full record

ReviewFrontiers in physiology2018

Osteoclast-Derived Extracellular Vesicles: Novel Regulators of Osteoclastogenesis and Osteoclast-Osteoblasts Communication in Bone Remodeling.

Feng-Lai Yuan, Qian-Yuan Wu, Zong-Ning Miao, Ming-Hui Xu, Rui-Sheng Xu, Dong-Lin Jiang, Jun-Xing Ye, Fei-Hu Chen, Ming-Dong Zhao, Hao-Jue Wang and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 115 citations in OpenAlex.

  1. Review
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  5. From pathogenesis to therapy: extracellular vesicles in osteoarthritis.Frontiers in bioengineering and biotechnology · 2026
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Feng-Lai YuanDepartment of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, China.
Qian-Yuan WuDepartment of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, China.
Zong-Ning MiaoDepartment of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, China.
Ming-Hui XuDepartment of Pediatrics, People's Hospital of Puyang, Puyang, China.
Rui-Sheng XuDepartment of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, China.
Dong-Lin JiangDepartment of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, China.
Jun-Xing YeDepartment of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, China.
Fei-Hu ChenCollege of Pharmacy, Anhui Medical University, Hefei, China.
Ming-Dong ZhaoDepartment of Orthopaedics, Jinshan Hospital, Fudan University, Shanghai, China.
Hao-Jue WangThe Department of Obstetrics and Gynecology, Wuxi Xishan People's Hospital, Jiangsu, China.
Xia LiDepartment of Orthopaedics and Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, China.
Wuxi Third People's Hospital · CNAnhui Medical University · CNJinshan Hospital of Fudan University · CNWuxi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play an important role in cellular communication during skeletal growth and homeostasis. Bioactive molecules carried by EVs are transported to neighboring and distant cells to trigger a series of signaling cascades influencing bone homeostasis. The bioactive activities of osteoclast-derived EVs include regulation of osteoclastogenesis and osteoclast-osteoblast communication. As osteoclast-derived EVs have the potential to regulate osteoclasts and osteoblasts, their application in osteoporosis and other bone metabolic disorders is currently under investigation. However, very few reviews of osteoclast-derived EVs in bone remodeling regulation have yet been published. This article aims to review recent advances in this field, summarizing a new regulator of osteoclastogenesis and osteoclast-osteoblast communication mediated by osteoclast-derived EVs. We will analyze the major challenges in the field and potential for the therapeutic application of EVs.

Indexed as

bone remodelingcommunicationextracellular vesiclesosteoclastogenesisosteoclasts

Identifiers

PMID29910740
PMCPMC5992398
OpenAlexW2807444964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.