Evidence map›Paper›PMID 29910735›Full record

ArticleFrontiers in physiology2018

Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension.

Tinne C J Mertens, Ankit Hanmandlu, Ly Tu, Carole Phan, Scott D Collum, Ning-Yuan Chen, Tingting Weng, Jonathan Davies, Chen Liu, Holger K Eltzschig and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  5. SETD2 drives METTL14-mediated mCellular and molecular life sciences : CMLS · 2025
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  6. Review
  7. Ivy Leaf Dry Extract EA 575International journal of molecular sciences · 2023
    Article
  8. Review
  9. Review
  10. Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Purinergic Dysfunction in Pulmonary Arterial Hypertension.Journal of the American Heart Association · 2020
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Tinne C J MertensDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Ankit HanmandluDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Ly TuInstitut National de la Santé et de la Recherche Médicale UMR_S 999, Le Plessis-Robinson, France.
Carole PhanInstitut National de la Santé et de la Recherche Médicale UMR_S 999, Le Plessis-Robinson, France.
Scott D CollumDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Ning-Yuan ChenDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Tingting WengDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Jonathan DaviesDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Chen LiuDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Holger K EltzschigDepartment of Anesthesiology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Soma S K JyothulaDepartment of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Keshava RajagopalDepartment of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Yang XiaDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Ashrith GuhaMethodist Debakey Heart and Vascular Center, Houston Methodist Hospital, Houston, TX, United States.
Brian A BrucknerMethodist Debakey Heart and Vascular Center, Houston Methodist Hospital, Houston, TX, United States.
Michael R BlackburnDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Christophe GuignabertInstitut National de la Santé et de la Recherche Médicale UMR_S 999, Le Plessis-Robinson, France.
Harry Karmouty-QuintanaDepartment of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
The University of Texas Health Science Center at Houston · USHouston Methodist · USAR2i · FRBaylor College of Medicine · USInserm · FRUniversité Paris-Saclay · FR

Funding

Trangenic Mouse Breeding CoreP01HL114457 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHANG, YUJIN · 2013 to 2017
$10.0M
3'UTR Shortening In Pulmonary Vascular DiseaseR01HL138510 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARMOUTY-QUINTANA, HARRY · 2017 to 2021
$2.3M
Proton Pump Inhibitors for Perioperative Acute Kidney InjuryR01DK097075 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2013 to 2017
$1.7M
Amphiregulin Signaling in Perioperative Cardio-ProtectionR01HL119837 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2014 to 2017
$1.5M
MicroRNA Shuttling during Acute Respiratory Distress SyndromeR01HL133900 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2017 to 2020
$1.5M
NHLBI NIH HHS P01 HL114457NHLBI NIH HHS R01 HL119837NHLBI NIH HHS R01 HL133900NHLBI NIH HHS R01 HL138510NIDDK NIH HHS R01 DK097075
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Group III PHGroup I PHhyaluronanlung fibrosistissue transglutaminasevascular remodeling

Identifiers

PMID29910735
PMCPMC5992271
OpenAlexW2800299042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.