Evidence map›Paper›PMID 29910731›Full record

ArticleFrontiers in pharmacology2018

Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons.

Ginetta Collo, Laura Cavalleri, Michele Zoli, Uwe Maskos, Emiliangelo Ratti, Emilio Merlo Pich

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. "Unraveling the role ofReceptors (Basel, Switzerland) · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Neurotoxicity of e-cigarettes.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020
    Review
  7. Translational Molecular Approaches in Substance Abuse Research.Handbook of experimental pharmacology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

Ginetta ColloSection of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Laura CavalleriSection of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Michele ZoliDepartment of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, Modena, Italy.
Uwe MaskosUnité de Neurobiologie Intégrative des Systèmes Cholinergiques, CNRS UMR 3571, Institut Pasteur, Paris, France.
Emiliangelo RattiNeuroscience Therapeutic Area Unit, Takeda Pharmaceuticals International Co., Cambridge, MA, United States.
Emilio Merlo PichThe Division of Brain Science, Imperial College London, London, United Kingdom.
Centre National de la Recherche Scientifique · FRImperial College London · GBTakeda (Switzerland) · CHUniversity of Basel · CHUniversity of Brescia · ITUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Midbrain dopamine (DA) neurons are considered a critical substrate for the reinforcing and sensitizing effects of nicotine and tobacco dependence. While the role of the α4 and β2 subunit containing nicotinic acetylcholine receptors (α4β2

Indexed as

alpha-conotoxinsdendrite outgrowthdopaminergic systeminduced pluripotent stem cellsneural plasticitynicotine dependencetranslational

Identifiers

PMID29910731
PMCPMC5992464
OpenAlexW2805046736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.