ReviewInternational journal of medical sciences2018
Lipid Emulsion for Treating Local Anesthetic Systemic Toxicity.
Review in International journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06988982 (Lipid Emulsion for Reversal of Spinal Anesthesia in Ambulatory Surgery), which is not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lipid Emulsion for Reversal of Spinal Anesthesia in Ambulatory Surgery: A Randomized Controlled Trial
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.
- Effectiveness of treatments for propranolol toxicity: a systematic review of current approaches and evidence.European journal of clinical pharmacology · 2026Pooled it
- Molecular Mechanisms of Local Anesthetic Toxicity: From Ion Channel Dysregulation to Mitochondrial Dysfunction and Tissue-Specific Injury.International journal of molecular sciences · 2026Review
- Cytoprotective Effects of Lipid Emulsion Against Bupivacaine-Induced Cytotoxicity in Human Rotator Cuff Fibroblasts.Antioxidants (Basel, Switzerland) · 2026Article
- [Lipid rescue as a bail-out strategy in a repeatedly resuscitated patient].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Article
- Local Anesthetic Toxicity in Epidural Analgesia for Elderly Patients: A Case Report.Case reports in anesthesiology · 2026Article
- Case Report: Local anaesthetic systemic toxicity secondary to presumed thoracostomy tube migration through the aortic hiatus in a dog.Frontiers in veterinary science · 2026Article
- Differential recovery of ventricular repolarization and hemodynamics following bupivacaine and ropivacaine intoxication: the impact of lipophilicity on lipid emulsion efficacy.Frontiers in pharmacology · 2026Article
- A survey of anaesthetic management of regional anaesthesia for patients undergoing arthroscopic shoulder surgery in Australia.BMC anesthesiology · 2025Article
- Current and Developing Approaches for Facilitating Emergence from General Anesthesia.Anesthesiology · 2025Review
- Intravenous Lipid Emulsion Therapy in Drug Overdose and Poisoning: An Updated Review.The Eurasian journal of medicine · 2024Article
- The possible therapeutic role of intravenous lipid emulsion in acute aluminium phosphide poisoning: a randomized controlled clinical trial.Toxicology research · 2024Article
- Administration of Intravenous Lipid Emulsion for Dextromethorphan Poisoning with Serotonin Syndrome: A Case Report.Journal of personalized medicine · 2024Article
- Lipid emulsion inhibits the cardiac toxicity caused by chloroquine via inhibition of reactive oxygen species production.Korean journal of anesthesiology · 2023Article
- Article
- Mechanisms underlying lipid emulsion resuscitation for drug toxicity: a narrative review.Korean journal of anesthesiology · 2023Review
- Lipid emulsion for xenobiotic overdose: PRO.British journal of clinical pharmacology · 2023Article
- The Pain Management of Trauma Patients in the Emergency Department.Journal of clinical medicine · 2023Review
- Possible Brainstem Anaesthesia in a Cat after Ultrasound-Guided Retrobulbar Block.Animals : an open access journal from MDPI · 2023Article
- Lipid emulsion-induced recovery from unconsciousness caused by lidocaine toxicity: A case report.SAGE open medical case reports · 2023Article
- Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics.Drug design, development and therapy · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid emulsion has been shown to be an effective treatment for systemic toxicity induced by local anesthetics, which is reflected in case reports. A systemic review and meta-analysis confirm the efficacy of this treatment. Investigators have suggested mechanisms associated with the lipid emulsion-mediated recovery of cardiovascular collapse caused by local anesthetic systemic toxicity; these mechanisms include lipid sink, a widely accepted theory in which highly soluble local anesthetics (particularly bupivacaine) are absorbed into the lipid phase of plasma from tissues (e.g., the heart) affected by local-anesthetic-induced toxicity; enhanced redistribution (lipid shuttle); fatty acid supply; reversal of mitochondrial dysfunction; inotropic effects; glycogen synthase kinase-3β phosphorylation associated with inhibition of the mitochondrial permeability transition pore opening; inhibition of nitric oxide release; and reversal of cardiac sodium channel blockade. The current review includes the following: 1) an introduction, 2) a list of the proposed mechanisms, 3) a discussion of the best lipid emulsion treatment for reversal of local anesthetic toxicity, 4) a description of the effect of epinephrine on lipid emulsion-mediated resuscitation, 5) a description of the recommended lipid emulsion treatment, and 6) a conclusion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.