ArticleIndian journal of anaesthesia2018
Attenuation of the pressor responses to laryngoscopy and endotracheal intubation with intravenous dexmedetomidine versus magnesium sulphate under bispectral index-controlled anaesthesia: A placebo-controlled prospective randomised trial.
Article in Indian journal of anaesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05941767 (Comparing Intravenous Versus Nebulized Either Lidocaine or Dexmedetomidine for Attenuation of the Hemodynamic Responses to Laryngoscopy and Intubation), which is not on this map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing Intravenous Versus Nebulized Either Lidocaine or Dexmedetomidine for Attenuation of the Hemodynamic Responses to Laryngoscopy and Intubation
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Bilateral Superior Laryngeal Nerve Block to Attenuate the Pressor Response of Laryngoscopy and Intubation in Adult Patients Undergoing Elective Surgeries Under General Endotracheal Anesthesia: A Randomized Controlled Double-blind Study.Annals of African medicine · 2026Trial
- The Effect of Dexmedetomidine Nasal Spray on Extubation-Related Stress Response and Delayed Extubation After Laparoscopic Surgery: A Randomized Controlled Trial.Therapeutics and clinical risk management · 2025Trial
- Effect of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation: a randomized control trial.Korean journal of anesthesiology · 2021Trial
- Comparison of Three Different Doses of Dexmedetomidine for Attenuation of the Pressor Response to Laryngoscopy and Intubation by Assessment of Haemodynamic Parameters and Plasma Catecholamine Levels Under Bi-spectral Index Guided Anaesthesia - A Randomised Double Blind Controlled Study.Turkish journal of anaesthesiology and reanimation · 2026Article
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- Dexmedetomidine Versus Fentanyl in Intraoperative Neuromuscular Monitoring Using A Propofol-based Total Intravenous Anaesthesia Regimen in Spine Surgeries.Turkish journal of anaesthesiology and reanimation · 2024Article
- The impact of magnesium on shivering incidence in cardiac surgery patients: A systematic review.Heliyon · 2024Article
- Bispectral index-guided comparison of dexmedetomidine and fentanyl as an adjuvant with propofol to achieve an adequate depth for endotracheal intubation - A double-blind randomised controlled trial.Indian journal of anaesthesia · 2024Article
- Nebulised fentanyl, dexmedetomidine and magnesium sulphate for attenuation of haemodynamic response to laryngoscopy and tracheal intubation: A double-blinded, randomised comparative study.Indian journal of anaesthesia · 2023Article
- Assessment of haemodynamic response to tracheal intubation and prone positioning following clonidine and enalaprilat in lumbar spine surgeries: A double blind randomised controlled trial.Indian journal of anaesthesia · 2023Article
- Dexmedetomidine vs. Fentanyl-Midazolam Combination to Mitigate the Stress Response in Microlaryngoscopy: A Randomized Double-blind Clinical Trial.Anesthesiology and pain medicine · 2023Article
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- Article
- Comparison of Intravenous Versus Nebulized Dexmedetomidine for Laryngoscopy and Intubation-Induced Sympathoadrenal Stress Response Attenuation.Anesthesiology and pain medicine · 2022Article
- Article
- Evaluation of nebulised dexmedetomidine in blunting haemodynamic response to intubation: A prospective randomised study.Indian journal of anaesthesia · 2020Article
- Comparative evaluation of oral melatonin and oral clonidine for the attenuation of haemodynamic response to laryngoscopy and tracheal intubation-A prospective randomised double blind study.Indian journal of anaesthesia · 2020Article
- Attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation with dexmedetomidine: A comparison between intravenous and intranasal route.Indian journal of anaesthesia · 2019Article
- Post operative sore throat: Comparison between Macintosh versus Video Laryngoscope in patients intubated by trainee anaesthetists - A Randomised Control Trial.Pakistan journal of medical sciencesArticle
- Effect of Preoperative Intravenous and Inhalational Dexmedetomidine on the Hemodynamic Response of Laryngoscopy: A Prospective Double-blinded Randomized Study.Journal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsLaryngoscopy and intubation cause sympathetic stimulation and arousal reactions. We evaluated the role of dexmedetomidine and magnesium sulphate on pressor responses to laryngoscopy and intubation as compared to placebo, when depth of anaesthesia was maintained at a constant bispectral index (BIS) range 40-50 (±5).
methodsOne hundred and twenty patients were randomised to receive either dexmedetomidine 1 μg/kg (Group DS), magnesium sulphate 30 mg/kg diluted in 100 ml saline (Group MS) or 100 ml normal saline (Group NS) 15 min before induction of anaesthesia in a double blind manner. After achieving BIS 40-50 (±5), laryngoscopy and intubation were performed. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded pre-drug, after drug, at intubation, at intervals of 1 min till 5 min, then every 2 min till 10 min and every 10 min for 30 min. Statistical analysis was done using Chi-square test and one way analysis of variance.
resultsSBP, DBP and HR fell in the DS and MS groups. No significant changes in BP were seen in the NS group at induction and after intubation. HR rose in the NS group (
conclusionAt BIS levels 40-50 (±5) there was no pressor response to intubation in the NS Group. Dexmedetomidine and magnesium sulphate significantly reduced the heart rate and blood pressure from baseline.
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