ArticleCurrent biology : CB2018
Encoding of Target Detection during Visual Search by Single Neurons in the Human Brain.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 50 citations in OpenAlex.
- A web-based spot-the-difference paradigm for studying social information processing in naturalistic visual scenes.Behavior research methods · 2026Article
- Combined eye tracking and electroencephalography during referential selection in dyadic interaction.Behavior research methods · 2026Article
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- Computational neural dynamics of goal-directed visual attention in macaques.Science advances · 2026Article
- Computational single-neuron mechanisms of visual object coding in the human temporal lobe.Nature communications · 2026Article
- Feature-based encoding of face identity by single neurons in the human amygdala and hippocampus.Nature human behaviour · 2025Article
- Single-neuron datasets for linguistic and semantic processing in the human amygdala and hippocampus.Scientific data · 2025Article
- Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans.Cell reports · 2025Article
- A large neuronal dataset for natural category-based free-gaze visual search in macaques.Scientific data · 2025Article
- A neural computational framework for face processing in the human temporal lobe.Current biology : CB · 2025Article
- Distinct attentional characteristics of neurons with visual feature coding in the primate brain.Science advances · 2025Article
- A neuronal code for object representation and memory in the human amygdala and hippocampus.Nature communications · 2025Article
- A human single-neuron dataset for object recognition.Scientific data · 2025Article
- Saccades track visual associative memory processes with precision and sensitivity.Brain communications · 2025Article
- Domain-specific representation of social inference by neurons in the human amygdala and hippocampus.Science advances · 2024Article
- Behavioral and Neural Mechanisms of Face-Specific Attention during Goal-Directed Visual Search.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distinct visual processing networks for foveal and peripheral visual fields.Communications biology · 2024Article
- Encoding of Visual Objects in the Human Medial Temporal Lobe.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Multimodal single-neuron, intracranial EEG, and fMRI brain responses during movie watching in human patients.Scientific data · 2024Article
- Neural mechanisms of face familiarity and learning in the human amygdala and hippocampus.Cell reports · 2024Article
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Authors and funding
4 authors at 3 institutions in 1 country.
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Abstract
Neurons in the primate medial temporal lobe (MTL) respond selectively to visual categories such as faces, contributing to how the brain represents stimulus meaning. However, it remains unknown whether MTL neurons continue to encode stimulus meaning when it changes flexibly as a function of variable task demands imposed by goal-directed behavior. While classically associated with long-term memory, recent lesion and neuroimaging studies show that the MTL also contributes critically to the online guidance of goal-directed behaviors such as visual search. Do such tasks modulate responses of neurons in the MTL, and if so, do their responses mirror bottom-up input from visual cortices or do they reflect more abstract goal-directed properties? To answer these questions, we performed concurrent recordings of eye movements and single neurons in the MTL and medial frontal cortex (MFC) in human neurosurgical patients performing a memory-guided visual search task. We identified a distinct population of target-selective neurons in both the MTL and MFC whose response signaled whether the currently fixated stimulus was a target or distractor. This target-selective response was invariant to visual category and predicted whether a target was detected or missed behaviorally during a given fixation. The response latencies, relative to fixation onset, of MFC target-selective neurons preceded those in the MTL by ∼200 ms, suggesting a frontal origin for the target signal. The human MTL thus represents not only fixed stimulus identity, but also task-specified stimulus relevance due to top-down goal relevance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.