Evidence map›Paper›PMID 29909540›Full record

ReviewJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2018

A contemporary view of atrioventricular nodal physiology.

Steven M Markowitz, Bruce B Lerman

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04232371 (Randomized Clinical Trial for Treatment of Atrioventricular Nodal Reentry Tachycardia), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04232371 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Randomized Clinical Trial for Treatment of Atrioventricular Nodal Reentry Tachycardia (AVNRT): Low Voltage and Wave Front Collision Mapping vs. Anatomic/Electrogram Approach to Slow AV Nodal Pathway Ablation

TypeinterventionalSponsorJeffrey MoakRan2020 to 2023Enrolled300ConditionsSupraventricular TachycardiaArmsNew Ablation Technique, Standard Ablation Technique
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Article
  6. Article
  7. Activation pattern within Koch's triangle during sinus rhythm in patients with and without atrioventricular nodal reentrant tachycardia.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024
    Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Steven M MarkowitzDepartment of Medicine, Division of Cardiology, Weill Cornell Medical Center, 525 East 68th Street, New York, NY, 10065, USA. smarkow@med.cornell.edu.ORCID http://orcid.org/0000-0002-3401-8933
Bruce B LermanDepartment of Medicine, Division of Cardiology, Weill Cornell Medical Center, 525 East 68th Street, New York, NY, 10065, USA.
Cornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In delaying transmission of the cardiac impulse from the atria to the ventricles, the atrioventricular (AV) node serves a critical function in augmenting ventricular filling during diastole and limiting the ventricular response during atrial tachyarrhythmias. The complex structure of the nodal region, however, also provides the substrate for reentrant rhythms. Recent discoveries have elucidated the cellular basis and anatomical determinants of slow conduction in the node. Based on analysis of gap junction proteins, distinct structural components of the AV node have been defined, including the compact node, right and left inferior nodal extensions, the lower nodal bundle, and transitional tissue. Emerging evidence supports the role of the inferior nodal extensions in mediating slow pathway conduction. The most common form of reentry involving the node, slow-fast AV nodal reentrant tachycardia (AVNRT), utilizes the inferior nodal extensions for anterograde slow pathway conduction; the structures responsible for retrograde fast pathway activation in the superior septum are less well defined and likely heterogeneous. Atypical forms of AVNRT arise from circuits that activate at least one of the inferior extensions in the retrograde direction.

Indexed as

Atrioventricular NodeBundle of HisCatheter AblationElectrocardiographyFemaleHeart Conduction SystemHumansIncidenceMalePrognosisRisk AssessmentTachycardia, Atrioventricular Nodal ReentryAtrioventricular nodal reentrant tachycardiaAtrioventricular nodeDual pathway physiology

Identifiers

PMID29909540
OpenAlexW2808237491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.