Evidence map›Paper›PMID 29909471›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2018

PET/CT and prediction of thyroid cancer in patients with follicular neoplasm or atypia.

Thao T Nguyen, Natascha G E Lange, Anne L Nielsen, Anders Thomassen, Helle Døssing, Christian Godballe, Max Rohde

Abstract read
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Quantitative classification and radiomics of [European journal of nuclear medicine and molecular imaging · 2022
    Trial
  3. Article
  4. Article
  5. Review
  6. Preoperative stratification of cytologically indeterminate thyroid nodules by [European journal of nuclear medicine and molecular imaging · 2023
    Article
  7. Review
  8. Thyroid : official journal of the American Thyroid Association · 2021
    Article
  9. Performance ofJournal of clinical medicine · 2019
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thao T NguyenDepartment of ORL, Head and Neck Surgery, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark. Btng91@gmail.com.
Natascha G E LangeDepartment of ORL, Head and Neck Surgery, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark. Nataschalange@hotmail.com.ORCID http://orcid.org/0000-0003-3989-7364
Anne L NielsenDepartment of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
Anders ThomassenDepartment of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
Helle DøssingDepartment of ORL, Head and Neck Surgery, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark.
Christian GodballeDepartment of ORL, Head and Neck Surgery, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark.
Max RohdeDepartment of ORL, Head and Neck Surgery, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine whether addition of MATERIALS AND

methodsConsecutive patients with FNAB-derived follicular neoplasm or atypia planned for surgery from September 2013 to March 2016 were prospectively included and considered for analysis. All patients underwent preoperative PET/CT and a clinical head and neck examination, including ultrasound of the neck and the thyroid gland. Patients with obvious signs of thyroid malignancy were excluded from the study. Histology of the surgical specimen was used as reference standard for statistical analysis.

resultsOf the 108 patients included (85 women, median age 53.4 years), 31 (29%) had a thyroid nodule that was histologically verified as malignant. Sensitivity and specificity for PET/CT in detection of thyroid cancer was 79 and 32%, respectively, including a derived positive predictive value (PPV) of 31%, and a negative predictive value (NPV) of 79%. Univariate and multivariate analyses showed no significant increase in the risk of thyroid cancer among patients with focal or multifocal FDG uptake compared to patients with no FDG uptake.

conclusionAddition of PET/CT to FNAB did not improve prediction of thyroid cancer in patients with FNAB-derived follicular neoplasm or atypia.

Indexed as

Positron Emission Tomography Computed TomographyAdultAgedAged, 80 and overBiopsy, Fine-NeedleCohort StudiesFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedSensitivity and SpecificityThyroid NeoplasmsThyroid NoduleUltrasonographyYoung AdultFluorodeoxyglucose F18AtypiaFluoro-deoxy-glucose uptake (FDG uptake)Follicular neoplasmPositron emission tomography/computed tomography (PET/CT)Thyroid nodule

Identifiers

PMID29909471

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.