Evidence map›Paper›PMID 29909300›Full record

ArticleJournal of affective disorders2018

Parsing cyclothymic disorder and other specified bipolar spectrum disorders in youth.

Anna Van Meter, Benjamin I Goldstein, Tina R Goldstein, Shirley Yen, Heather Hower, Michael Strober, John A Merranko, Mary Kay Gill, Rasim S Diler, David Axelson and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. The Regulatory Potential of Long Non-Coding RNAs in Bipolar Disorder.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Anna Van MeterThe Feinstein Institute for Medical Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA. Electronic address: avanmeter@northwell.edu.
Benjamin I GoldsteinDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto Faculty of Medicine, 2075 Bayview Ave., FG-53, Toronto, ON M4N-3M5, Canada.
Tina R GoldsteinDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
Shirley YenDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI 02912, USA; Butler Hospital, 700 Butler Drive, Providence, RI 02906, USA.
Heather HowerDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G-BH, Providence, RI 02912, USA.
Michael StroberDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, 760 Westwood Plaza, Mail Code 175919, Los Angeles, CA 90095, USA.
John A MerrankoDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
Mary Kay GillDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
Rasim S DilerDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
David AxelsonDepartment of Psychiatry, Nationwide Children's Hospital and The Ohio State College of Medicine, 1670 Upham Dr., Columbus, OH 43210, USA.
Neal D RyanDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
Martin B KellerButler Hospital, 700 Butler Drive, Providence, RI 02906, USA.
Boris BirmaherDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA 15213, USA.
University of Pittsburgh · USProvidence College · USBrown University · USFeinstein Institute for Medical Research · USNationwide Children's Hospital · USSunnybrook Health Science Centre · CAUniversity of California, Los Angeles · US

Funding

Course and Outcome of Bipolar Disorder in Youth - SupplementR01MH059929 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS, PHILLIPS, MARY LOUISE · 2000 to 2021
$15.9M
Course and Outcome for Bipolar Disorder in Youth (COBY)R01MH059691 · NIMH · BROWN UNIVERSITY · PI KELLER, MARTIN B, YEN, SHIRLEY · 2000 to 2015
$7.9M
Response Evaluation of Acute Cortisol in mTBI (REACT)R01MH114881 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Anthony P Kontos, Amelia Versace · 2018 to 2026
$6.2M
Course and Outcome for Bipolar Disorder in YouthR01MH059977 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI STROBER, MICHAEL A · 2000 to 2010
$3.7M
1/2 Predicting Adult Outcomes in Bipolar Youth (PROBY)R01MH112544 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS · 2018 to 2022
$2.5M
2/2-Predicting Adult Outcomes in Bipolar Youth (PROBY)R01MH112543 · NIMH · BROWN UNIVERSITY · PI YEN, SHIRLEY · 2018 to 2022
$1.2M
NIMH NIH HHS R01 MH059691NIMH NIH HHS R01 MH059929NIMH NIH HHS R01 MH059977NIMH NIH HHS R01 MH112543NIMH NIH HHS R01 MH112544
6 · The paper itself

Abstract

objectiveMost studies of pediatric bipolar disorder (BP) combine youth who have manic symptoms, but do not meet criteria for BP I/II, into one "not otherwise specified" (NOS) group. Consequently, little is known about how youth with cyclothymic disorder (CycD) differ from youth with BP NOS. The objective of this study was to determine whether youth with a research diagnosis of CycD (RDCyc) differ from youth with operationalized BP NOS.

methodParticipants from the Course and Outcome of Bipolar Youth study were evaluated to determine whether they met RDCyc criteria. Characteristics of RDCyc youth and BP NOS youth were compared at baseline, and over eight-years follow-up.

resultsOf 154 youth (average age 11.96 (3.3), 42% female), 29 met RDCyc criteria. RDCyc youth were younger (p = .04) at baseline. Over follow-up, RDCyc youth were more likely to have a disruptive behavior disorder (p = .01), and were more likely to experience irritability (p = .03), mood reactivity (p = .02), and rejection sensitivity (p = .03). BP NOS youth were more likely to develop hypomania (p = .02), or depression (p = .02), and tended to have mood episodes earlier in the eight-year follow-up period. LIMITATIONS: RDCyc diagnoses were made retrospectively and followed stringent criteria, which may highlight differences that, under typical clinical conditions and more vague criteria, would not be evident.

conclusionThere were few differences between RDCyc and BP NOS youth. However, the ways in which the groups diverged could have implications; chronic subsyndromal mood symptoms may portend a severe, but ultimately non-bipolar, course. Longer follow-up is necessary to determine the trajectory and outcomes of CycD symptoms.

Indexed as

AdolescentAttention Deficit and Disruptive Behavior DisordersBipolar DisorderChildCyclothymic DisorderDiagnosis, DifferentialFemaleHumansIrritable MoodMaleProportional Hazards ModelsRetrospective StudiesBipolar disorderCyclothymic disorderDiagnosisLongitudinalYouth

Identifiers

PMID29909300
PMCPMC6322201
OpenAlexW2805277784

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.