Evidence map›Paper›PMID 29909116›Full record

ArticlePharmacological research2018

Altered microRNA regulation of short chain fatty acid receptors in the hypertensive kidney is normalized with hydrogen sulfide supplementation.

Gregory J Weber, Jaleyea Foster, Sathnur B Pushpakumar, Utpal Sen

Open access · greenAbstract read
In one paragraph

Article in Pharmacological research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Gut Microbiota-Derived Short-Chain Fatty Acids Driven by N-Carbamylglutamate Alleviates Premature Ovarian Failure Through Suppressing Ferroptosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. The interplay of hydrogen sulfide and microRNAs in cardiovascular diseases: insights and future perspectives.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Protective effect ofChinese herbal medicines · 2023
    Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gregory J WeberDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States.
Jaleyea FosterDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States.
Sathnur B PushpakumarDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States.
Utpal SenDepartment of Physiology, University of Louisville, School of Medicine, Louisville, KY, 40202, United States. Electronic address: u0sen001@louisville.edu.
University of Louisville · US

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
Hydrogen sulfide mechanism of renal hypertensionR01DK104653 · NIDDK · UNIVERSITY OF LOUISVILLE · PI SEN, UTPAL, TYAGI, SURESH C. · 2015 to 2018
$2.5M
NIDDK NIH HHS R01 DK104653NIGMS NIH HHS P20 GM103436
6 · The paper itself

Abstract

Hypertension affects nearly one third of the adult US population and is a significant risk factor for chronic kidney disease (CKD). An expanding body of recent studies indicates that gut microbiome has crucial roles in regulating physiological processes through, among other mechanisms, one mode of short chain fatty acids (SCFA) and their target receptors. In addition, these SCFA receptors are potential targets of regulation by host miRNAs, however, the mechanisms through which this occurs is not clearly defined. Hydrogen sulfide (H

Indexed as

AnimalsAntihypertensive AgentsCells, CulturedDisease Models, AnimalDysbiosisFatty Acids, VolatileGastrointestinal MicrobiomeGlomerular Filtration RateHydrogen SulfideHypertensionKidneyMaleMice, Inbred C57BLMicroRNAsMorpholinesOrganothiophosphorus CompoundsAntihypertensive AgentsFatty Acids, VolatileGYY 4137Hydrogen SulfideMicroRNAsMorpholinesOrganothiophosphorus CompoundsReceptors, G-Protein-CoupledGut microbiomeHydrogen sulfideMicroRNAShort chain fatty acid

Identifiers

PMID29909116
PMCPMC6086735
OpenAlexW2808104002

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.