Evidence map›Paper›PMID 29908948›Full record

ArticleNeuroscience letters2019

Multiplexed calcium imaging of single-synapse activity and astroglial responses in the intact brain.

James P Reynolds, Kaiyu Zheng, Dmitri A Rusakov

Abstract read
In one paragraph

Article in Neuroscience letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  10. Review
  11. Article
  12. Single Synapse Indicators of Impaired Glutamate Clearance Derived from Fast iGluThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

James P ReynoldsUCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. Electronic address: james.reynolds@ucl.ac.uk.
Kaiyu ZhengUCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Dmitri A RusakovUCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. Electronic address: d.rusakov@ucl.ac.uk.

Funding

Medical Research Council G0900613Wellcome Trust 212251/Z/18/Z
6 · The paper itself

Abstract

All-optical registration of neuronal and astrocytic activities within the intact mammalian brain has improved significantly with recent advances in optical sensors and biophotonics. However, relating single-synapse release events and local astroglial responses to sensory stimuli in an intact animal has not hitherto been feasible. Here, we present a multiplexed multiphoton excitation imaging approach for assessing the relationship between presynaptic Ca

Indexed as

AnimalsAstrocytesAxonsBrainCalciumCalcium SignalingFemaleMaleMiceMice, Inbred C57BLMicroscopy, Fluorescence, MultiphotonNeuronsPresynaptic TerminalsSomatosensory CortexSynapsesCalciumAstrocytesMultiphoton imagingNeurotransmissionTripartite synapse

Identifiers

PMID29908948
PMCPMC6335263

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.