Evidence map›Paper›PMID 29908790›Full record

ArticleInternational journal of radiation oncology, biology, physics2018

Association of Neuronal Injury in the Genu and Body of Corpus Callosum After Cranial Irradiation in Children With Impaired Cognitive Control: A Prospective Study.

Kristin J Redmond, Meghan Hildreth, Haris I Sair, Stephanie Terezakis, Todd McNutt, Lawrence Kleinberg, Kenneth J Cohen, Moody Wharam, Alena Horska, E Mark Mahone

Abstract read
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In one paragraph

Article in International journal of radiation oncology, biology, physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Early region-specific impact of adjuvant radiation therapy on cognition and quality of life in adult patients with primary brain tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  6. Article
  7. Article
  8. Observational
  9. Decoding Patient Heterogeneity Influencing Radiation-Induced Brain Necrosis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  10. Article
  11. Deformation-based morphometry: a sensitive imaging approach to detect radiation-induced brain injury?Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Article
  12. Total-Body Irradiation Alters White Matter Volume and Microstructural Integrity in Rhesus Macaques.International journal of radiation oncology, biology, physics · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
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  20. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Kristin J RedmondDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, Maryland. Electronic address: kjanson3@jhmi.edu.
Meghan HildrethDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, Maryland.
Haris I SairRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, Maryland.
Stephanie TerezakisDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, Maryland.
Todd McNuttDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, Maryland.
Lawrence KleinbergDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, Maryland.
Kenneth J CohenDivision of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland.
Moody WharamDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, Maryland.
Alena HorskaRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, Maryland.
E Mark MahoneDepartment of Neuropsychology, Kennedy Krieger Institute, Baltimore, Maryland.

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI KRAUT, MICHAEL A · 2014 to 2019
$7.9M
Metabolic effects of brain radiation in childrenR01NS042851 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HORSKA, ALENA · 2003 to 2006
$1.3M
NCATS NIH HHS UL1 TR003098NCRR NIH HHS UL1 RR025005NICHD NIH HHS U54 HD079123NINDS NIH HHS R01 NS042851
6 · The paper itself

Abstract

purposeBrain radiation is associated with functional deficits in children. The purpose of this study was to examine white matter integrity as measured by diffusion tensor imaging and associations with region-specific radiation dose and neuropsychological functioning in children treated with cranial irradiation. METHODS AND MATERIALS: A total of 20 patients and 55 age- and sex-matched controls were included in the present study. Diffusion tensor imaging and neuropsychological assessments were conducted at baseline and 6, 15, and 27 months after treatment. The neuropsychological assessment included motor dexterity, working memory, and processing speed. White matter regions were contoured, and the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were recorded for each participant. Linear mixed effects regression models were used to prospectively compare the associations among ADC, FA, radiation dose to contoured structures, and performance on the neuropsychological assessments over time.

resultsThe mean prescription dose was 44 Gy (range 12-54). Across visits, compared with the controls, the patients showed a significantly increased ADC across all selected regions and alterations in FA in the dorsal midbrain and corpus callosum (genu, splenium, body). An increased radiation dose to the genu and body of the corpus callosum was associated with alterations in ADC and FA and reduced neuropsychological performance, most notably motor speed and processing.

conclusionsThese prospective data suggest that subcortical white matter, especially the genu and body of the corpus callosum, could be regions with increased susceptibility to radiation-induced injury, with implications for cognitive function.

Indexed as

AdolescentAnisotropyBehaviorBrainBrain NeoplasmsCase-Control StudiesChildChild, PreschoolCognitionCorpus CallosumDiffusion Tensor ImagingFemaleHumansMaleNeuronsNeuropsychological Tests

Identifiers

PMID29908790
PMCPMC6050077

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.