Trial reportFertility and sterility2018
Insulin resistance is associated with depression risk in polycystic ovary syndrome.
Trial report in Fertility and sterility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Depression, anxiety and self-esteem in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Effects of weight loss intervention on anxiety, depression and quality of life in women with severe obesity and polycystic ovary syndrome.Scientific reports · 2024Trial
- Efficacy of high-intensity interval training for improving mental health and health-related quality of life in women with polycystic ovary syndrome.Scientific reports · 2023Trial
- Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial.BMC women's health · 2022Trial
- Trial
- Association between combined oral contraceptive pills and depression in women with polyendocrine metabolic ovarian syndrome (formerly polycystic ovary syndrome): a comparative cross-sectional study.BMC women's health · 2026Article
- Models of care on the management of women with polycystic ovary syndrome: A multicentre study.Endocrine · 2026Observational
- Kisspeptin mediates the impact of chronic psychological stress on reproductive and metabolic dysregulation in polycystic ovary syndrome: evidence from human and rat models.Journal of ovarian research · 2025Article
- The Role of Gut-Brain Tryptophan Metabolism and Fatty Acid Peroxidation in the Effect of Sleep Deprivation on Anxiety and Depression in PCOS Mice.Molecular neurobiology · 2025Article
- Gut microbiota and ovarian diseases: a new therapeutic perspective.Journal of ovarian research · 2025Review
- Dietary Patterns and Metabolic and Hormonal Parameters in Women with Suspected PCOS.Journal of clinical medicine · 2025Article
- Association between depressive symptoms and thyroid nodule incidence in women: a prospective observational study.BMC public health · 2025Observational
- Review
- Association of insulin resistance surrogates with live birth outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization.BMC pregnancy and childbirth · 2025Article
- Dietary Factors and the Risk of Depression among Women with Polycystic Ovary Syndrome.Nutrients · 2024Article
- [Endocrine and psychosomatic disorders in patients with amenorrhea].Problemy endokrinologii · 2024Review
- Association between different insulin resistance surrogates and infertility in reproductive-aged females.BMC public health · 2023Article
- Obesity and hyperandrogenism are implicated with anxiety, depression and food cravings in women with polycystic ovary syndrome.Endocrine · 2023Article
- Virgin coconut oil reverses behavioral phenotypes of letrozole-model of PCOS in Wistar rats via modulation of NRF2 upregulation.Journal of Taibah University Medical Sciences · 2023Article
- Impact of Insulin Resistance on Ovarian Sensitivity and Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome Undergoing IVF.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS).
designSecondary analysis of data from a multicenter randomized trial.
settingMulticenter university-based clinical practices. PATIENT(S): Seven hundred thirty-eight women with PCOS by modified Rotterdam criteria seeking pregnancy enrolled in a randomized clinical trial comparing clomiphene citrate versus letrozole. INTERVENTION(S): The Primary Care Evaluation of Mental Disorders Patient Health Questionnaire was self-administered to identify depression using a validated algorithm at enrollment. Demographic and anthropometric data were collected, and serum assays were performed. Insulin resistance was estimated using the homeostatic model of insulin resistance (HOMA-IR), with a cutoff of >2.2 considered abnormal. MAIN OUTCOME MEASURE(S): Demographic, endocrine, and metabolic parameters associated with depression. RESULT(S): In a univariate logistic regression analysis, elevated HOMA-IR was associated with 2.3-fold increased odds of depression (odds ratio [OR] = 2.32; 95% confidence interval [CI], 1.28-4.21). This association remained significant after controlling for age and body mass index (adjusted OR [aOR] = 2.23; 95% CI, 1.11-4.46) and in a model including additional potential confounders (aOR = 2.03; 95% CI, 1.00-4.16). CONCLUSION(S): Insulin resistance has a strong and independent association with depression in PCOS and may serve as a physiologic mediator. Our findings corroborate a growing body of evidence linking insulin resistance to depressed mood. The association between insulin resistance and depressed mood warrants further investigation to elucidate mechanisms and identify potential therapeutic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.