SynthesisPreventive medicine2018
Acceptability and feasibility of naloxone prescribing in primary care settings: A systematic review.
Synthesis in Preventive medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Reducing perceived barriers to scaling up overdose education and naloxone distribution and medications for opioid use disorder in the United States in the HEALing (Helping End Addiction Long-Term®) communities study.Preventive medicine · 2024Trial
- Factors associated with withdrawal symptoms and anger among people resuscitated from an opioid overdose by take-home naloxone: Exploratory mixed methods analysis.Journal of substance abuse treatment · 2020Trial
- Impact of Clinical Pharmacy Team Intervention on Naloxone Fills in Patients on ChroCnic Opioid Therapy.The Permanente journal · 2025Article
- Rural providers' attitudes toward integrating harm reduction strategies and PrEP prescribing into rural primary care settings in the US. Southeast and Midwest.Addiction science & clinical practice · 2025Article
- Primary Care Patient and Clinician Perspectives on Safer Use Strategies for Opioids and/or Stimulants: A Mixed-Method Study.Journal of general internal medicine · 2025Article
- Missouri naloxone distribution 2017-2023: Evaluation and implications of applying a naloxone saturation model.Journal of substance use and addiction treatment · 2025Article
- Iterative Development of a Clinical Decision Support Tool to Enhance Naloxone Coprescribing.Applied clinical informatics · 2025Article
- A theoretical explanation of naloxone provision among primary care physicians and community pharmacists in Tennessee.Research in social & administrative pharmacy : RSAP · 2024Article
- Effects of pharmacist-driven protocol on naloxone prescribing rates in two primary care clinics.Preventive medicine reports · 2023Article
- Overdose education and naloxone distribution program design informed by people who use drugs and naloxone distributors.Preventive medicine reports · 2023Article
- Patient perspectives on naloxone receipt in the emergency department: a qualitative exploration.Harm reduction journal · 2022Article
- Associations between naloxone prescribing and opioid overdose among patients with acute and chronic pain conditions.Addiction (Abingdon, England) · 2022Article
- The impact of access to addiction specialist on attitudes, beliefs and hospital-based opioid use disorder related care: A survey of hospitalist physicians.Substance abuse · 2022Article
- UNDERSTANDING PREFERENCES FOR TYPE OF TAKE-HOME NALOXONE DEVICE: INTERNATIONAL QUALITATIVE ANALYSIS OF THE VIEWS OF PEOPLE WHO USE OPIOIDS.Drugs (Abingdon, England) · 2022Article
- Substance abuse and neurotransmission.Advances in pharmacology (San Diego, Calif.) · 2022Article
- Effectiveness and implementability of state-level naloxone access policies: Expert consensus from an online modified-Delphi process.The International journal on drug policy · 2021Article
- Impact of policy changes on the provision of naloxone by pharmacies in Ontario, Canada: a population-based time-series analysis.Addiction (Abingdon, England) · 2021Article
- Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review.BMC public health · 2021Article
- "Health Is on the Back Burner:" Multilevel Barriers and Facilitators to Primary Care Among People Who Inject Drugs.Journal of general internal medicine · 2021Article
- Opportunities to boost naloxone awareness among people who misuse opioid analgesics who have not used illegal opioids.Substance abuse · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Naloxone access through established healthcare settings is critical to responding to the opioid crisis. We conducted a systematic review to assess the acceptability and feasibility of prescribing naloxone to patients in primary care. We queried PubMed, EmBase and CINAHL for US-based, peer-reviewed, full-length, original articles relating to acceptability or feasibility of prescribing naloxone in primary care. Searches yielded 270 unduplicated articles; one analyst reviewed all titles and abstracts. Two analysts independently reviewed eligible articles for study design, study outcome, and acceptability and/or feasibility. Analyses were compared and a third reviewer consulted if discrepancies emerged. Seventeen articles were included. Providers' willingness to prescribe naloxone appeared to increase over time. Most studies provided prescribers in-person naloxone trainings, including how to write a prescription and indications for prescribing. Most studies implemented universal prescribing, whereby anyone prescribed long-term opioids or otherwise at risk for overdose was eligible for naloxone. Patient education was largely provided by prescribers and most studies provided take-home educational materials. Providers reported concerns around naloxone prescribing including lack of knowledge around prescribing and educating patients. Providers also reported benefits such as improving difficult conversations around opioids and resetting the culture around opioids and overdose. Current literature supports the acceptability and feasibility of naloxone prescribing in primary care. Provision of naloxone through primary care may help normalize such medication safety interventions, support larger opioid stewardship efforts, and expand access to patients not served by a community distribution program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.