ArticleJournal of shoulder and elbow surgery2018
Cutibacterium acnes and the shoulder microbiome.
Article in Journal of shoulder and elbow surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Article
- Synovial Fluid-derived Micrococcus Luteus G18 Exacerbates Osteoarthritis Progression by Promoting Chondrocyte Degradation via TLR2/JNK/AP-1 Signaling Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Patient and Surgeon Variables Associated With a Diagnosis of Shoulder Periprosthetic Joint Infection.The archives of bone and joint surgery · 2025Article
- Joint Microbiota Suggests Articular Dysbiosis in Experimental Murine Spondyloarthritis and Histological Detection of Bacteria in Human SpA Joints.International journal of inflammation · 2025Article
- The shoulder microbiome: a systematic review and meta analysis.JSES reviews, reports, and techniques · 2024Review
- Native intra-articular knee microbiome is a matter of facts: a systematic review of clinical evidence.EFORT open reviews · 2024Article
- Upper extremity infection: imaging features with focus on magnetic resonance imaging.Skeletal radiology · 2024Review
- Management of periprosthetic joint infection of the shoulder: A narrative review.Journal of clinical orthopaedics and trauma · 2024Article
- A Literature Review of Cutibacterium Acnes: From Skin Commensal to Pathogen in Shoulder Surgery.Cureus · 2024Review
- Are Cutibacterium acnes delivered from skin to deep tissues in primary reverse shoulder arthroplasty? A prospective study.Archives of orthopaedic and trauma surgery · 2024Article
- C.acnes in the joint, is it all just a false positive?European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Article
- Next-Generation Sequencing Supports Targeted Antibiotic Treatment for Culture Negative Orthopedic Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Review
- Detection ofRevista brasileira de ortopedia · 2022Article
- Short-term Clinical Outcomes of Unexpected Culture-positive Cutibacterium acnes (Formerly Propionibacterium acnes) in Open Orthopaedic Surgery.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Article
- Patient compliance and satisfaction with topical benzoyl peroxide gel prior to shoulder surgery.JSES international · 2022Article
- The management of the shoulder skin microbiome (Shoulder & elbow · 2021Article
- Effectiveness of decontamination protocols when analyzing ancient DNA preserved in dental calculus.Scientific reports · 2021Article
- Ten-day culture incubation time can accurately detect bacterial infection in periprosthetic infection in shoulder arthroplasty.JSES international · 2020Article
- Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvances in DNA sequencing technologies have made it possible to detect microbial genome sequences (microbiomes) within tissues once thought to be sterile. We used this approach to gain insights into the likely sources of Cutibacterium acnes (formerly Propionibacterium acnes) infections within the shoulder.
methodsTissue samples were collected from the skin, subcutaneous fat, anterior supraspinatus tendon, middle glenohumeral ligament, and humeral head cartilage of 23 patients (14 male and 9 female patients) during primary arthroplasty surgery. Total DNA was extracted and microbial 16S ribosomal RNA sequencing was performed using an Illumina MiSeq system. Data analysis software was used to generate operational taxonomic units for quantitative and statistical analyses.
resultsAfter stringent removal of contamination, genomic DNA from various Acinetobacter species and from the Oxalobacteraceae family was identified in 74% of rotator cuff tendon tissue samples. C acnes DNA was detected in the skin of 1 male patient but not in any other shoulder tissues.
conclusionOur findings indicate the presence of a low-abundance microbiome in the rotator cuff and, potentially, in other shoulder tissues. The absence of C acnes DNA in all shoulder tissues assessed other than the skin is consistent with the hypothesis that C acnes infections are derived from skin contamination during surgery and not from opportunistic expansion of a resident C acnes population in the shoulder joint.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.