ArticleEpilepsy & behavior : E&B2018
Anxiety is common and independently associated with clinical features of epilepsy.
Article in Epilepsy & behavior : E&B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Systematic literature review of the humanistic and economic burden of focal epilepsy and primary generalized tonic-clonic seizures in adults.Epilepsia open · 2024Pooled it
- Implementing electronic health record-based anxiety and depression screening in an epilepsy clinic: Theory-based implementation strategy and pre-post quantitative outcomes using Reach, Effectiveness, Adoption, Implementation, and Maintenance.Journal of clinical and translational science · 2025Article
- Cognitive behavioral interventions for depression and anxiety in adults with neurological disorders: a systematic review and meta-analysis.Psychological medicine · 2024Review
- Influence of Epilepsy Characteristics on the Anxiety Occurrence.Brain sciences · 2024Article
- Article
- Afraid to go out: Poor quality of life with phobic anxiety in a large cross-sectional adult epilepsy center sample.Epilepsy research · 2023Article
- Risk analysis of depression among adult patients with epilepsy of different sex: a retrospective single-center study from China.Frontiers in psychiatry · 2023Article
- Suicide and Epilepsy.Current neurology and neuroscience reports · 2022Review
- Factors not considered in the study of drug-resistant epilepsy: Psychiatric comorbidities, age, and gender.Epilepsia open · 2022Review
- Perceived quality of life (QOLIE-31-P), depression (NDDI-E), anxiety (GAD-7), and insomnia in patients with epilepsy attended at a refractory epilepsy unit in real-life clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Observational
- Remote and Long-Term Self-Monitoring of Electroencephalographic and Noninvasive Measurable Variables at Home in Patients With Epilepsy (EEG@HOME): Protocol for an Observational Study.JMIR research protocols · 2021Article
- Predictors of Comorbid Anxiety Symptoms After a New Diagnosis of Epilepsy: A Prospective 12-Month Follow-Up Observation.Frontiers in neurology · 2021Article
- Epilepsy control during an epidemic: emerging approaches and a new management framework.Acta epileptologica · 2020Review
- Pleiotropy of polygenic factors associated with focal and generalized epilepsy in the general population.PloS one · 2020Article
- Bilateral anterior capsulotomy enhances medication compliance in patients with epilepsy and psychiatric comorbidities.CNS neuroscience & therapeutics · 2019Article
- Psychiatric comorbidity and quality of life in patients with epilepsy on anti-epileptic monotherapy and polytherapy.Tzu chi medical journalArticle
- Article
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3 authors.
Funding
Abstract
objectiveThe objective of this study was to assess for independent association of anxiety symptoms with epilepsy localization and other epilepsy-related and demographic factors in a large tertiary care adult epilepsy population.
methodsAmong 540 adults, anxiety was measured by the Symptom Checklist 90-R (SCL-90R) anxiety subscale, and detailed demographics, epilepsy localization, and depression scores (SCL-90R) were collected. High anxiety was defined by SCL-90R anxiety T-score ≥ 60. Stepwise multiple logistic regression was carried out to assess for independent association of high anxiety scores with demographic and clinical factors.
resultsHigh anxiety symptoms were present in 46.1% of participants (N = 250). Focal or unknown epilepsy type and depression scores were independently associated with high anxiety (adjusted odds ratios (OR): 2.89 (95% confidence interval [CI] = 1.33-6.29, p = 0.007) and 2.12 (95% CI = 1.83-2.45, p < 0.001), respectively; depression odds per 5-point increase in scale). Among the focal epilepsy subpopulation, mesial temporal sclerosis was also independently associated with high anxiety, with adjusted OR: 2.12 (95% CI = 1.11-4.04, p = 0.023). Lower education, non-white race/ethnicity, Spanish native language, prior head trauma, antiseizure drug polytherapy, and left focus or bilateral foci (in focal epilepsy) were associated with high anxiety in simple logistic regression, but these associations were not independent. A total of 46 individuals (18.4% of those with high anxiety) scored high for anxiety but not depression. Only 26% of those with high anxiety symptoms were taking a potentially anxiolytic medication.
conclusionAnxiety symptoms, often without concomitant depression, were highly prevalent in this epilepsy sample and independently associated with focal/unknown epilepsy and mesial temporal sclerosis. These results strongly support the value of screening specifically for anxiety in the epilepsy clinic, to direct patients to appropriate treatment.
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