Evidence map›Paper›PMID 29908362›Full record

SynthesisClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2019

Magnetic Resonance vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual Participants.

Cynthia Hsu, Cyrielle Caussy, Kento Imajo, Jun Chen, Siddharth Singh, Kellee Kaulback, Minh-Da Le, Jonathan Hooker, Xin Tu, Ricki Bettencourt and 5 more

Abstract readComparative StudyEvaluation StudySystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 224 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
224citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

224 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Pooled it
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164 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Cynthia HsuNonalcoholic Fatty Liver Disease Research Center, Department of Medicine, University of California, San Diego, La Jolla, California.
Cyrielle CaussyNonalcoholic Fatty Liver Disease Research Center, Department of Medicine, University of California, San Diego, La Jolla, California; Université Lyon 1, Department of Medicine, Hospices Civils de Lyon, Lyon, France.
Kento ImajoDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Jun ChenDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Siddharth SinghNonalcoholic Fatty Liver Disease Research Center, Department of Medicine, University of California, San Diego, La Jolla, California; Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California.
Kellee KaulbackResearch in Practice, Toronto, Ontario, Canada.
Minh-Da LeNonalcoholic Fatty Liver Disease Research Center, Department of Medicine, University of California, San Diego, La Jolla, California.
Jonathan HookerLiver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, California.
Xin TuDivision of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, California.
Ricki BettencourtNonalcoholic Fatty Liver Disease Research Center, Department of Medicine, University of California, San Diego, La Jolla, California.
Meng YinDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Claude B SirlinLiver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, California.
Richard L EhmanDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Atsushi NakajimaDepartment of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Rohit LoombaNonalcoholic Fatty Liver Disease Research Center, Department of Medicine, University of California, San Diego, La Jolla, California; Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California; Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California. Electronic address: roloomba@ucsd.edu.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Comprehensive noninvasive assessment of liver histopathology in nonalcoholic fatty liver disease (NAFLD) via magnetic resonance imaging, cytometry and elastography (MR-ICE)R01EB017197 · NIBIB · MAYO CLINIC ROCHESTER · PI YIN, MENG · 2014 to 2025
$4.3M
Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
QUS Technology for Diagnosis and Grading of Hepatic Steatosis in NAFLDR01DK106419 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT, SIRLIN, CLAUDE B · 2015 to 2019
$3.4M
Magnetic Resonance ElastographyR01EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2003 to 2013
$3.1M
Comparative Risks and Benefits of Pharmacological Therapies for Older Patients with Inflammatory Bowel DiseasesK23DK117058 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SINGH, SIDDHARTH · 2018 to 2022
$971k
GENETIC EPIDEMIOLOGY OF NONALCOHOLIC FATTY LIVER DISEASEK23DK090303 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT · 2011 to 2014
$721k
San Diego Clinical and Translational Research InstituteKL2RR031978 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$615k
NCATS NIH HHS UL1 TR001442NCRR NIH HHS KL2 RR031978NIBIB NIH HHS R01 EB001981NIBIB NIH HHS R01 EB017197NIBIB NIH HHS R37 EB001981NIDDK NIH HHS K23 DK090303NIDDK NIH HHS K23 DK117058NIDDK NIH HHS R01 DK106419
6 · The paper itself

Abstract

BACKGROUND &

aimsMagnetic resonance elastography (MRE) and transient elastography (TE) are noninvasive techniques for detection of liver fibrosis. Single-center studies have compared the diagnostic performance of MRE vs TE in patients with nonalcoholic fatty liver disease (NAFLD). We conducted a pooled analysis of individual participant data from published studies to compare the diagnostic performance of MRE vs TE for staging of liver fibrosis in patients with NAFLD, using liver biopsy as reference.

methodsWe performed a systematic search of publication databases, from 2005 through 2017. We identified 3 studies of adults with NAFLD who were assessed by MRE, TE, and liver biopsy. In a pooled analysis, we calculated the cluster-adjusted area under the curve (AUROC) of MRE and TE for the detection of each stage of fibrosis. AUROC comparisons between MRE and TE were performed using the Delong test.

resultsOur pooled analysis included 230 participants with biopsy-proven NAFLD with mean age of 52.2±13.9 years and a body mass index of 31.9±7.5 kg/m2. The proportions of patients with fibrosis of stages 0, 1, 2, 3, and 4 were: 31.7%, 27.8%, 15.7%, 13.9%, and 10.9%, respectively. The AUROC of TE vs MRE for detection of fibrosis stages ≥1 was 0.82 (95% CI, 0.76-0.88) vs 0.87 (95% CI, 0.82-0.91) (P=.04); for stage≥ 2 was 0.87 (95% CI, 0.82-0.91) vs 0.92 (95% CI, 0.88-0.96) (P=.03); for stage ≥3 was 0.84 (95% CI, 0.78-0.90) vs 0.93 (95% CI, 0.89-0.96) (P=.001); for stage ≥ 4 was 0.84 (95% CI, 0.73-0.94) vs 0.94 (95% CI, 0.89-0.99) (P=.005).

conclusionIn a pooled analysis of data from individual participants with biopsy-proven NAFLD, we found MRE to have a statistically significantly higher diagnostic accuracy than TE in detection of each stage of fibrosis. MRE and TE each have roles in detection of fibrosis in patients with NAFLD, depending upon the level of accuracy desired.

Indexed as

AdultAgedAged, 80 and overDiagnostic Tests, RoutineElasticity Imaging TechniquesFemaleHumansLiver CirrhosisMagnetic Resonance ImagingMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseROC CurveFibroscanMagnetic Resonance ElastographyNAFLDTransient Elastography

Identifiers

PMID29908362
PMCPMC6294709

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.