ArticleActa psychiatrica Scandinavica2018
Bipolar disorder type I and II show distinct relationships between cortical thickness and executive function.
Article in Acta psychiatrica Scandinavica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum.Schizophrenia bulletin · 2021Pooled it
- The St. Göran Project: A Multipronged Strategy for Longitudinal Studies for Bipolar Disorders.Neuropsychobiology · 2025Article
- Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder.Molecular psychiatry · 2024Article
- Mania-related effects on structural brain changes in bipolar disorder - a narrative review of the evidence.Molecular psychiatry · 2023Review
- Potential scalp stimulation targets for mental disorders: evidence from neuroimaging studies.Journal of translational medicine · 2021Article
- Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature.Brain sciences · 2021Review
- Structural and Functional Brain Correlates of Neuroprogression in Bipolar Disorder.Current topics in behavioral neurosciences · 2021Article
- Level of play and coach-rated game intelligence are related to performance on design fluency in elite soccer players.Scientific reports · 2020Article
- Article
- Neuropsychological profiles of adult bipolar disorder patients with and without comorbid attention-deficit hyperactivity disorder.International journal of bipolar disorders · 2019Article
- Bipolar disorder type I and II show distinct relationships between cortical thickness and executive function.Acta psychiatrica Scandinavica · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveFrontal cortical abnormalities and executive function impairment co-occur in bipolar disorder. Recent studies have shown that bipolar subtypes differ in the degree of structural and functional impairments. The relationships between cognitive performance and cortical integrity have not been clarified and might differ across patients with bipolar disorder type I, II, and healthy subjects.
methodUsing a vertex-wise whole-brain analysis, we investigated how cortical integrity, as measured by cortical thickness, correlates with executive performance in patients with bipolar disorder type I, II, and controls (N = 160).
resultsWe found focal associations between executive function and cortical thickness in the medial prefrontal cortex in bipolar II patients and controls, but not in bipolar I disorder. In bipolar II patients, we observed additional correlations in lateral prefrontal and occipital regions.
conclusionsOur findings suggest that bipolar disorder patients show altered structure-function relationships, and importantly that those relationships may differ between bipolar subtypes. The findings are line with studies suggesting subtype-specific neurobiological and cognitive profiles. This study contributes to a better understanding of brain structure-function relationships in bipolar disorder and gives important insights into the neuropathophysiology of diagnostic subtypes.
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