SynthesisPediatric radiology2018
Feasibility of quantitative ultrasonography for the detection of metabolic bone disease in preterm infants - systematic review.
Synthesis in Pediatric radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Pooled it
- Revisiting the radiographic assessment of osteoporosis-Osteopenia in children 0-2 years of age. A systematic review.PloS one · 2020Pooled it
- Inter-rater and intra-rater reliability of quantitative ultrasound in preterm infants: an observational cohort study.JBMR plus · 2026Article
- Challenges in assessing bone health in early infancy: a narrative review of existing technologies.Frontiers in endocrinology · 2025Review
- Skeletal consequences of preterm birth in pigs as a model for preterm infants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Diagnostics of Metabolic Bone Disease in Extremely Preterm Infants-Clinical Applicability of Bone Turnover Biochemical Markers and Quantitative Ultrasound.Children (Basel, Switzerland) · 2024Article
- A Multidisciplinary and a Comprehensive Approach to Reducing Fragility Fractures in Preterm Infants.Current pediatric reviews · 2024Review
- Pulsed Vibro-Acoustic Analysis Technique for Monitoring Bone Health in Preterm Infants: A Pilot Study.IEEE access : practical innovations, open solutions · 2024Article
- Developmental factors influencing bone strength in precocial mammals: An infant pig model.Journal of anatomy · 2023Article
- Early elevated alkaline phosphatase as a surrogate biomarker of ongoing metabolic bone disease of prematurity.European journal of pediatrics · 2023Observational
- The role of quantitative ultrasound in diagnosing severe bone metabolic diseases in newborns.Frontiers in pediatrics · 2023Article
- Incidence, Risk Factors and Prediction of Secondary Hyperparathyroidism in Preterm Neonates under 32 Weeks' Gestational Age.Nutrients · 2022Article
- Are Children Suffering From Congenital Pseudarthrosis of the Tibia Associated With Decreased Bone Strength?Frontiers in pediatrics · 2022Article
- Is quantitative ultrasound a measure for metabolic bone disease in preterm-born infants? A prospective subcohort study.European journal of pediatrics · 2021Article
- Expert consensus on clinical management of metabolic bone disease of prematurity (2021).Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Comparison of prevalence and characteristics of fractures in term and preterm infants in the first 3 years of life.Pediatric radiology · 2021Article
- Convolutional Neural Network-Based Humerus Segmentation and Application to Bone Mineral Density Estimation from Chest X-ray Images of Critical Infants.Diagnostics (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic bone disease of prematurity is characterised by disordered bone mineralisation and is therefore an increased fracture risk. Preterm infants are especially at risk due to incomplete in utero bone accretion during the last trimester. Currently, diagnosing metabolic bone disease mainly relies on biochemistry and radiographs. Dual-energy x-ray absorptiometry and quantitative ultrasound (US) are used less frequently. However, biochemical measurements correlate poorly with bone mineralisation and although scoring systems exist for metabolic bone disease, radiographs are subjective and do not detect early features of osteopenia. Dual energy x-ray absorptiometry is the reference standard for determining bone density in older children and adults. However, challenges with this method include movement artefact, difficulty scanning small and sick infants and a lack of normative data for young children. Quantitative US has a relatively low cost, is radiation-free and portable, and may hence be suitable for assessing bone status in preterm infants. This review aims to provide an overview of the use of quantitative US in detecting metabolic bone disease in preterm infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.