Evidence map›Paper›PMID 29907870›Full record

ArticleMucosal immunology2018

Synergistic activation of pro-inflammatory type-2 CD8

Bart Hilvering, Timothy S C Hinks, Linda Stöger, Emanuele Marchi, Maryam Salimi, Rahul Shrimanker, Wei Liu, Wentao Chen, Jian Luo, Simei Go and 16 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 59 citations in OpenAlex.

  1. Trial
  2. The PGDCommunications biology · 2026
    Article
  3. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Type 2 immunity in allergic diseases.Cellular & molecular immunology · 2025
    Review
  7. Article
  8. Review
  9. Altered COVID-19 immunity in children with asthma by atopic status.The journal of allergy and clinical immunology. Global · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Type-2 CD8Nature communications · 2023
    Article
  14. T helper 2 cells in asthma.The Journal of experimental medicine · 2023
    Review
  15. T-cell responses in asthma exacerbations.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 1 country.

Bart HilveringRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Timothy S C HinksRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Linda StögerRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Emanuele MarchiTranslational Gastroenterology Unit and Peter Medawar Building, Nuffield Department of Medicine, University of Oxford, South Parks Rd, Oxford, UK.
Maryam SalimiMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Rahul ShrimankerRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Wei LiuRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Wentao ChenRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Jian LuoRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Simei GoRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Timothy PowellRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Jennifer CaneRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Samantha ThulbornRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Ayako KuriokaTranslational Gastroenterology Unit and Peter Medawar Building, Nuffield Department of Medicine, University of Oxford, South Parks Rd, Oxford, UK.
Tianqi LengTranslational Gastroenterology Unit and Peter Medawar Building, Nuffield Department of Medicine, University of Oxford, South Parks Rd, Oxford, UK.
Jamie MatthewsTranslational Gastroenterology Unit and Peter Medawar Building, Nuffield Department of Medicine, University of Oxford, South Parks Rd, Oxford, UK.
Clare ConnollyRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Catherine BorgRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Mona BafadhelRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Christian B WillbergTranslational Gastroenterology Unit and Peter Medawar Building, Nuffield Department of Medicine, University of Oxford, South Parks Rd, Oxford, UK.
Adaikalavan RamasamyTranscriptomic Core Facility, The Jenner Institute, University of Oxford, Oxford, UK.
Ratko DjukanovićClinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton University Hospital, Southampton, UK.
Graham OggMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Ian D PavordRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Paul KlenermanTranslational Gastroenterology Unit and Peter Medawar Building, Nuffield Department of Medicine, University of Oxford, South Parks Rd, Oxford, UK.
Luzheng XueRespiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK. luzheng.xue@ndm.ox.ac.uk.
University of Oxford · GBJohn Radcliffe Hospital · GBMedawar Building for Pathogen Research · GBJenner Institute · GBMRC Human Immunology Unit · GBNIHR Southampton Respiratory Biomedical Research Unit · GBUniversity of Southampton · GB

Funding

Academy of Medical Sciences SGL011\1007Department of Health PDF-2013-06-052Medical Research Council G0701693Medical Research Council G116/150Medical Research Council MC_U137881017Medical Research Council MC_UU_00008/5Medical Research Council MC_UU_12010/5Wellcome Trust 088365Wellcome Trust 088365/Z/09/ZWellcome Trust 104553Wellcome Trust 104553/Z/14/ZWellcome Trust 109965Wellcome Trust 109965/Z/15/ZWellcome Trust WT109965MA
6 · The paper itself

Abstract

Human type-2 CD8

Indexed as

A549 CellsAsthmaCD8-Positive T-LymphocytesCell Line, TumorChemokinesCytokinesHumansHypersensitivityInflammationLeukotriene E4LipidsLymphocyte CountMast CellsProstaglandin D2Pulmonary EosinophiliaTh2 CellsChemokinesCytokinesLeukotriene E4LipidsProstaglandin D2

Identifiers

PMID29907870
PMCPMC6448764
OpenAlexW2807891717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.