Observational studyScientific reports2018
Multiparametric magnetic resonance imaging for quantitation of liver disease: a two-centre cross-sectional observational study.
Observational study in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05462093 (Clinical Application of Annual Liver Multiscan and MRCP+ in Primary Sclerosing Cholangitis), which is not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Application of Annual Liver Multiscan and MRCP+ in Primary Sclerosing Cholangitis: the CATCH-IT Study
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Diagnostic accuracy and clinical impact of MRI-based technologies for patients with non-alcoholic fatty liver disease: systematic review and economic evaluation.Health technology assessment (Winchester, England) · 2023Pooled it
- New anti-diabetic agents for the treatment of non-alcoholic fatty liver disease: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2023Pooled it
- Trial
- Electromyogram diagnosed chronic lumbar radiculopathy is highly associated with L4-S1 regional multifidus atrophy on magnetic resonance imaging.BMC musculoskeletal disorders · 2026Article
- Enhancing liver fibrosis measurement: Deep learning and uncertainty analysis across multi-center cohorts.Journal of pathology informatics · 2026Article
- AI portal tract detection and characterisation for a regional analysis of steatosis and inflammation in MASLD, MASH and AIH.Journal of clinical pathology · 2026Observational
- 1H MR Spectroscopy at 3T for Hepatic Choline Quantification in Healthy Young Women: A Translational Imaging Study with Dietary Correlation.Current medical imaging · 2026Article
- The role of healthy lifestyle in the association between hepatic fibro-inflammation and steatosis and brain aging-a cross-sectional study.Frontiers in aging neuroscience · 2026Article
- Generalizable, sequence-invariant deep learning image reconstruction for subspace-constrained quantitative MRI.Magnetic resonance in medicine · 2025Article
- Accurate and precise in vivo liver 3D TMagnetic resonance in medicine · 2025Article
- Noninvasive Methods for Assessing Liver Fibrosis and Steatosis.Gastroenterology & hepatology · 2024Article
- An integrated gene-to-outcome multimodal database for metabolic dysfunction-associated steatotic liver disease.Nature medicine · 2023Article
- The Role of the Multiparametric MRI LiverMultiScanCancers · 2023Review
- Impact of fat on the apparent T1 value of the liver: assessment by water-only derived T1 mapping.European radiology · 2023Article
- Optimal flip angles for in vivo liver 3D TMagnetic resonance in medicine · 2023Article
- Strategies and Techniques for Liver Magnetic Resonance Imaging: New and Pending Applications for Routine Clinical Practice.Korean journal of radiology · 2023Review
- Non-invasive biomarkers for liver inflammation in non-alcoholic fatty liver disease: present and future.Clinical and molecular hepatology · 2023Review
- A Framework for Evaluating the Technical Performance of Multiparameter Quantitative Imaging Biomarkers (mp-QIBs).Academic radiology · 2023Review
- Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease.International journal of biomedical imaging · 2023Article
- Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations.Polish journal of radiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 8 institutions in 1 country.
Funding
Abstract
LiverMultiScan is an emerging diagnostic tool using multiparametric MRI to quantify liver disease. In a two-centre prospective validation study, 161 consecutive adult patients who had clinically-indicated liver biopsies underwent contemporaneous non-contrast multiparametric MRI at 3.0 tesla (proton density fat fraction (PDFF), T1 and T2* mapping), transient elastography (TE) and Enhanced Liver Fibrosis (ELF) test. Non-invasive liver tests were correlated with gold standard histothological measures. Reproducibility of LiverMultiScan was investigated in 22 healthy volunteers. Iron-corrected T1 (cT1), TE, and ELF demonstrated a positive correlation with hepatic collagen proportionate area (all p < 0·001). TE was superior to ELF and cT1 for predicting fibrosis stage. cT1 maintained good predictive accuracy for diagnosing significant fibrosis in cases with indeterminate ELF, but not for cases with indeterminate TE values. PDFF had high predictive accuracy for individual steatosis grades, with AUROCs ranging from 0.90-0.94. T2* mapping diagnosed iron accumulation with AUROC of 0.79 (95% CI: 0.67-0.92) and negative predictive value of 96%. LiverMultiScan showed excellent test/re-test reliability (coefficients of variation ranging from 1.4% to 2.8% for cT1). Overall failure rates for LiverMultiScan, ELF and TE were 4.3%, 1.9% and 15%, respectively. LiverMultiScan is an emerging point-of-care diagnostic tool that is comparable with the established non-invasive tests for assessment of liver fibrosis, whilst at the same time offering a superior technical success rate and contemporaneous measurement of liver steatosis and iron accumulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.