Evidence map›Paper›PMID 29907695›Full record

ArticleThe EMBO journal2018

Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles.

Sander C Steenbeek, Thang V Pham, Joep de Ligt, Anoek Zomer, Jaco C Knol, Sander R Piersma, Tim Schelfhorst, Rick Huisjes, Raymond M Schiffelers, Edwin Cuppen and 2 more

Abstract read
In one paragraph

Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The interaction between oxidative stress and Schwann cells.Experimental biology and medicine (Maywood, N.J.) · 2026
    Review
  5. Embryonic reprogramming of the tumor vasculature reveals targets for cancer therapy.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Prospects and challenges of tissue-derived extracellular vesicles.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Migrasomes, a new mode of intercellular communication.Cell communication and signaling : CCS · 2023
    Review
  15. Senescent Secretome of Blind Mole RatInternational journal of molecular sciences · 2023
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sander C SteenbeekMolecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Thang V PhamOncoProteomics Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Joep de LigtDivision Biomedical Genetics, Center for Molecular Medicine, Oncode Institute, University Medical Centre Utrecht, Utrecht, The Netherlands.
Anoek ZomerOncode Institute, Hubrecht Institute-KNAW & University Medical Centre Utrecht, Utrecht, The Netherlands.
Jaco C KnolOncoProteomics Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Sander R PiersmaOncoProteomics Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Tim SchelfhorstOncoProteomics Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Rick HuisjesDepartment of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.
Raymond M SchiffelersDepartment of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.
Edwin CuppenDivision Biomedical Genetics, Center for Molecular Medicine, Oncode Institute, University Medical Centre Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-0400-9542
Connie R JimenezOncoProteomics Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands c.jimenez@vumc.nl j.v.rheenen@nki.nl.ORCID 0000-0002-3103-4508
Jacco van RheenenMolecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands c.jimenez@vumc.nl j.v.rheenen@nki.nl.ORCID 0000-0001-8175-1647

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent data showed that cancer cells from different tumor subtypes with distinct metastatic potential influence each other's metastatic behavior by exchanging biomolecules through extracellular vesicles (EVs). However, it is debated how small amounts of cargo can mediate this effect, especially in tumors where all cells are from one subtype, and only subtle molecular differences drive metastatic heterogeneity. To study this, we have characterized the content of EVs shed

Indexed as

AnimalsCell Line, TumorCell MovementExtracellular VesiclesMelanoma, ExperimentalMiceNeoplasm MetastasisRNA, MessengerSignal TransductionTumor MicroenvironmentRNA, MessengerCre‐LoxPextracellular vesiclesintratumoral heterogeneityintravital microscopysignaling networks

Identifiers

PMID29907695
PMCPMC6068466

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.