Evidence map›Paper›PMID 29907692›Full record

ArticleScience immunology2018

Who regulates whom: ZNF341 is an additional player in the STAT3/T

Avery August

Abstract readComment
In one paragraph

Article in Science immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. JMJD3 PromotesDNA and cell biology · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. A deep intronic splice mutation ofProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Avery AugustDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. Email: averyaugust@cornell.edu.ORCID 0000-0003-4968-3415
Cornell University · US

Funding

Itk mediated tuning of CD8+ memory T cell developmentR01AI120701 · NIAID · CORNELL UNIVERSITY · PI AUGUST, AVERY · 2016 to 2019
$1.5M
Itk signaling and Type 1 regulatory T cell differentiation and function in allergic airway inflammationR21AI129422 · NIAID · CORNELL UNIVERSITY · PI AUGUST, AVERY, HUANG, WEISHAN · 2018 to 2019
$431k
Controlling Th17 cells and responses in airway inflammation by tyrosine kinase ItkR21AI126814 · NIAID · CORNELL UNIVERSITY · PI AUGUST, AVERY · 2016 to 2017
$426k
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI120701NIAID NIH HHS R21 AI126814NIAID NIH HHS R21 AI129422
6 · The paper itself

Abstract

Deficiency of ZNF341, a transcription factor featuring 12 Cys2His2 zinc fingers that regulates the expression and autoinduction of STAT3 (signal transducer and activator of transcription 3), results in hyper-immunoglobulin E syndrome and defective T helper 17 cell differentiation in humans.

Indexed as

Job SyndromeCell DifferentiationGene Expression RegulationHumansSTAT3 Transcription FactorTh17 CellsSTAT3 protein, humanSTAT3 Transcription Factor

Identifiers

PMID29907692
PMCPMC6211796
OpenAlexW2808352121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.