ArticleReproduction (Cambridge, England)2018
NLRP3 in somatic non-immune cells of rodent and primate testes.
Article in Reproduction (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- The Liver-Testis Axis: Molecular Mechanisms and Clinical Implications.International journal of molecular sciences · 2026Review
- Inflammaging: Immune-Metabolic Crosstalk Between the Prostate-Testis and Musculoskeletal System.International journal of molecular sciences · 2026Review
- Article
- Sertoli cell aging: damage accumulation and epigenetic alterations affecting male fertility.Biogerontology · 2026Review
- Gasdermin D in macrophages drives orchitis by regulating inflammation and antigen presentation processes.EMBO molecular medicine · 2024Article
- The role of inflammasome dysregulation in obstructive and non-obstructive azoospermia: a comparative molecular analysis of blood, tissue, and seminal plasma.Frontiers in immunology · 2024Article
- Vitamin D protects spermatogonia and Sertoli cells from heat stress damage by inhibiting NLRP3.Frontiers in pediatrics · 2024Article
- Identification and verification of potential biomarkers in sertoli cell-only syndrome via bioinformatics analysis.Scientific reports · 2023Article
- What is the impact of inflammasome mechanisms on male infertility?Turkish journal of medical sciences · 2023Article
- Zishen Yutai Pill improves sperm quality and reduces testicular inflammation in experimental varicocele rats.Heliyon · 2023Article
- Rescuing fertility during COVID-19 infection: exploring potential pharmacological and natural therapeutic approaches for comorbidity, by focusing on NLRP3 inflammasome mechanism.Journal of assisted reproduction and genetics · 2023Review
- Focus on the role of NLRP3 inflammasome in the pathology of endometriosis: a review on molecular mechanisms and possible medical applications.Naunyn-Schmiedeberg's archives of pharmacology · 2023Review
- Prokineticin 2/PROK2 and Male Infertility.Biomedicines · 2022Review
- Diet-induced obesity impairs spermatogenesis: the critical role of NLRP3 in Sertoli cells.Inflammation and regeneration · 2022Article
- The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review.Basic and clinical andrology · 2022Review
- The Role of NLRP3 Inflammasome Activation and Oxidative Stress in Varicocele-Mediated Male Hypofertility.International journal of molecular sciences · 2022Review
- NLRP3 inflammasome: A joint, potential therapeutic target in management of COVID-19 and fertility problems.Journal of reproductive immunology · 2021Article
- Genes underlying the evolution of tetrapod testes size.BMC biology · 2021Article
- MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility.Life science alliance · 2021Article
- Palmitic Acid Targets Human Testicular Peritubular Cells and Causes a Pro-Inflammatory Response.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
Abstract
NLRP3 is part of the NLRP3 inflammasome and a global sensor of cellular damage. It was recently discovered in rodent Sertoli cells. We investigated NLRP3 in mouse, human and non-human primate (marmoset and rhesus macaque) testes, employing immunohistochemistry. Sertoli cells of all species expressed NLRP3, and the expression preceded puberty. In addition, peritubular cells of the adult human testes expressed NLRP3.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.