Evidence map›Paper›PMID 29907647›Full record

ArticleGenetics2018

Determinants of Base-Pair Substitution Patterns Revealed by Whole-Genome Sequencing of DNA Mismatch Repair Defective

Patricia L Foster, Brittany A Niccum, Ellen Popodi, Jesse P Townes, Heewook Lee, Wazim MohammedIsmail, Haixu Tang

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Extended sequence context shapes mutational bias inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Manufacturing DNA inMolecular therapy. Methods & clinical development · 2024
    Article
  16. Article
  17. Mutation bias and adaptation in bacteria.Microbiology (Reading, England) · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Patricia L FosterDepartment of Biology, Indiana University, Bloomington, Indiana 47405 plfoster@indiana.edu.ORCID 0000-0002-7236-4378
Brittany A NiccumDepartment of Biology, Indiana University, Bloomington, Indiana 47405.
Ellen PopodiDepartment of Biology, Indiana University, Bloomington, Indiana 47405.
Jesse P TownesDepartment of Biology, Indiana University, Bloomington, Indiana 47405.
Heewook LeeSchool of Informatics, Computing, and Engineering, Indiana University, Bloomington, Indiana 47405.ORCID 0000-0002-3528-6833
Wazim MohammedIsmailSchool of Informatics, Computing, and Engineering, Indiana University, Bloomington, Indiana 47405.
Haixu TangSchool of Informatics, Computing, and Engineering, Indiana University, Bloomington, Indiana 47405.ORCID 0000-0001-8963-8155
Indiana University Bloomington · US

Funding

TRAINING IN GENETICST32GM007757 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI KUMAR, JUSTIN P · 1985 to 2014
$8.1M
NIGMS NIH HHS T32 GM007757
6 · The paper itself

Abstract

Mismatch repair (MMR) is a major contributor to replication fidelity, but its impact varies with sequence context and the nature of the mismatch. Mutation accumulation experiments followed by whole-genome sequencing of MMR-defective

Indexed as

Amino Acid SubstitutionDNA Mismatch RepairDNA ReplicationEscherichia coliGenome, BacterialPoint MutationWhole Genome SequencingDNA polymerase fidelityDNA replication accuracymismatch repairmutation accumulationmutation hotspots

Identifiers

PMID29907647
PMCPMC6063221
OpenAlexW2949984071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.