Evidence map›Paper›PMID 29907571›Full record

ArticleThe Journal of biological chemistry2018

Synonymous nucleotide modification of the

Alexander C Bertalovitz, Marika L Osterbur Badhey, Thomas V McDonald

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  5. Population-specific variations inAntimicrobial agents and chemotherapy · 2024
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  6. Rapid Antibacterial Activity Assessment of Chimeric Lysins.International journal of molecular sciences · 2024
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  7. Review
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  9. Review
  10. MPEPE, a predictive approach to improve protein expression inComputational and structural biotechnology journal · 2022
    Article
  11. Article
  12. Article
  13. In vitro and in vivo cardiac toxicity of flavored electronic nicotine delivery systems.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexander C BertalovitzDepartment of Molecular Pharmacology, Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461; Department of Cardiovascular Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612.
Marika L Osterbur BadheyDepartment of Molecular Pharmacology, Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461.
Thomas V McDonaldDepartment of Molecular Pharmacology, Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, New York 10461; Department of Cardiovascular Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612. Electronic address: thomasmcdonald@health.usf.edu.
Albert Einstein College of Medicine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Functional Implications of Non-Coding Data in HERG-MRNAR01HL118437 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI MCDONALD, THOMAS V · 2014 to 2017
$1.7M
Extra-coding features of mRNA are essential for hERG channel functionF30HL126283 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI OSTERBUR BADHEY, MARIKA LEE · 2015 to 2018
$195k
NHLBI NIH HHS F30 HL126283NHLBI NIH HHS R01 HL118437NIGMS NIH HHS T32 GM007288
6 · The paper itself

Abstract

Synonymous nucleotide variation is increasingly recognized as a factor than can affect protein expression, but the underlying mechanisms are incompletely understood. Here, we investigated whether synonymous changes could affect expression of the potassium voltage-gated channel subfamily H member 2 (

Indexed as

Protein BiosynthesisSilent MutationTranscription, GeneticBase CompositionCodonERG1 Potassium ChannelHEK293 CellsHumansMembrane PotentialsNucleic Acid ConformationNucleotidesPatch-Clamp TechniquesPlasmidsProtein AggregatesProtein DomainsProtein EngineeringCodonERG1 Potassium ChannelKCNH2 protein, humanNucleotidesProtein AggregatesRNA, Messengergenetic diseasegenetic polymorphismhERGmRNApotassium channelprotein synthesistranscriptiontranslation

Identifiers

PMID29907571
PMCPMC6078446
OpenAlexW2808377936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.