Evidence map›Paper›PMID 29907530›Full record

ReviewTrends in cognitive sciences2018

Why Does the Cortex Reorganize after Sensory Loss?

Amy Kalia Singh, Flip Phillips, Lotfi B Merabet, Pawan Sinha

Abstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  9. Dark exposure reduces high-frequency hearing loss in C57BL/6J mice.bioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amy Kalia SinghDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Flip PhillipsDepartment of Psychology and Neuroscience, Skidmore College, Saratoga Springs, NY, USA.
Lotfi B MerabetLaboratory for Visual Neuroplasticity, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
Pawan SinhaDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: psinha@mit.edu.

Funding

Project Prakash: Development of Object Perception After Late Sight OnsetR01EY020517 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SINHA, PAWAN · 2011 to 2025
$8.9M
Audio-Haptic Virtual Environments for Large-Scale Navigation in the BlindR01EY019924 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI MERABET, LOTFI · 2010 to 2018
$3.5M
NEI NIH HHS R01 EY019924NEI NIH HHS R01 EY020517
6 · The paper itself

Abstract

A growing body of evidence demonstrates that the brain can reorganize dramatically following sensory loss. Although the existence of such neuroplastic crossmodal changes is not in doubt, the functional significance of these changes remains unclear. The dominant belief is that reorganization is compensatory. However, results thus far do not unequivocally indicate that sensory deprivation results in markedly enhanced abilities in other senses. Here, we consider alternative reasons besides sensory compensation that might drive the brain to reorganize after sensory loss. One such possibility is that the cortex reorganizes not to confer functional benefits, but to avoid undesirable physiological consequences of sensory deafferentation. Empirical assessment of the validity of this and other possibilities defines a rich program for future research.

Indexed as

Models, NeurologicalAnimalsCerebral CortexHumansNeuronal PlasticitySensory Deprivationcortical reorganizationmultimodal activationsplasticitysensory compensationsensory loss

Identifiers

PMID29907530
PMCPMC7382297

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.