ArticleSchizophrenia research2018
Reduced higher-dimensional resting state fMRI dynamism in clinical high-risk individuals for schizophrenia identified by meta-state analysis.
Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Large-scale brain dynamics are organized by a directional coordination hierarchy.bioRxiv : the preprint server for biology · 2026Article
- Static and Dynamic Dysconnectivity in Early Psychosis: Relationship With Symptom Dimensions.Schizophrenia bulletin · 2024Article
- The continuum of attention dysfunction: Evidence from dynamic functional network connectivity analysis in neurotypical adolescents.PloS one · 2023Article
- Predictive signature of static and dynamic functional connectivity for ECT clinical outcomes.Frontiers in pharmacology · 2023Article
- A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk.Journal of psychiatry and brain science · 2023Article
- Dynamic functional connectivity and its anatomical substrate reveal treatment outcome in first-episode drug-naïve schizophrenia.Translational psychiatry · 2021Article
- Dynamic Functional Connectivity Better Predicts Disability Than Structural and Static Functional Connectivity in People With Multiple Sclerosis.Frontiers in neuroscience · 2021Article
- Brain Density Clustering Analysis: A New Approach to Brain Functional Dynamics.Frontiers in neuroscience · 2021Article
- Whole-Brain Functional Network Connectivity Abnormalities in Affective and Non-Affective Early Phase Psychosis.Frontiers in neuroscience · 2021Article
- Reduced higher dimensional temporal dynamism in neurofibromatosis type 1.NeuroImage. Clinical · 2019Article
- Characterizing Rapid Fluctuations of Resting State Functional Connectivity in Demyelinating, Neurodegenerative, and Psychiatric Conditions: From Static to Time-Varying Analysis.Frontiers in neuroscience · 2019Review
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Authors and funding
8 authors.
Funding
Abstract
New techniques to investigate functional network connectivity in resting state functional magnetic resonance imaging data have recently emerged. One novel approach, called meta-state analysis, goes beyond the mere cross-correlation of time courses of distinct brain areas and explores temporal dynamism in more detail, allowing for connectivity states to overlap in time and capturing global dynamic behavior. Previous studies have shown that patients with chronic schizophrenia exhibit reduced neural dynamism compared to healthy controls, but it is not known whether these alterations extend to earlier phases of the illness. In this study, we analyzed individuals at clinical high-risk (CHR, n = 53) for developing psychosis, patients in an early stage of schizophrenia (ESZ, n = 58), and healthy controls (HC, n = 70). ESZ individuals exhibit reduced neural dynamism across all domains compared to HC. CHR individuals also show reduced neural dynamism but only in 2 out of 4 domains investigated. Overall, meta-state analysis adds information about dynamic fluidity of functional connectivity.
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Registered trials
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