ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2018
Understanding the impact of sex and gender in Alzheimer's disease: A call to action.
Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 484 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
484 citing papers in PubMed, 6 syntheses or guidelines pooled it, 816 citations in OpenAlex.
- Association of periodontitis and tooth loss with cognitive decline in the older adults - a systematic review.BMC oral health · 2026Pooled it
- Transcranial photobiomodulation therapy in older women regarding cognitive functions: a systematic review.Lasers in medical science · 2025Pooled it
- Wearable Technology, Smart Home Systems, and Mobile Apps for the Self‑Management of Patient Outcomes in Dementia Care: Systematic Review.Journal of medical Internet research · 2025Pooled it
- Sex differences inFrontiers in dementia · 2025Pooled it
- The role of microRNAs in understanding sex-based differences in Alzheimer's disease.Biology of sex differences · 2024Pooled it
- Effectiveness of Resistance Exercise on Cognitive Function in Animal Models of Alzheimer Disease: A Systematic Review and Meta-Analysis.The journal of prevention of Alzheimer's disease · 2024Pooled it
- Sociodemographic and Clinical Characteristics of People Living with Dementia and Their Associations with Unmet Healthcare Needs: Insights from the Baseline Assessment of the InDePendent Study.Journal of Alzheimer's disease : JAD · 2024Trial
- Gender bias in the diagnosis of Alzheimer's Disease.Research square · 2026Article
- Estrogen deprivation exacerbates Alzheimer's disease pathology through neuronal CTSS signaling.Journal of neuroinflammation · 2026Article
- Plasma Concentrations of Amyloid-β Peptides, BACE-1, and Tau Proteins in Alzheimer's Disease.Turkish journal of pharmaceutical sciences · 2026Article
- Association between reproductive history, white matter integrity, and cognition in post-menopausal Latina women from the Boston Latino Aging Study.Journal of clinical and experimental neuropsychology · 2026Observational
- Cerebral Intramural Cells: A Missing Cellular Link Between Vascular Aging and Alzheimer's Disease.International journal of molecular sciences · 2026Review
- Exercise and Brain Health in Postmenopausal Women: A Review of Cognitive Benefits, Mechanisms, and Neurodegeneration Prevention.NeuroSci · 2026Review
- Sex-Specific Structural Vulnerability in Alzheimer's Disease: Insights from APOE ε 4-Negative Patients.Life (Basel, Switzerland) · 2026Article
- Estradiol and memory circuitry in the postmenopause: Modification by APOE4.Research square · 2026Article
- Tau-PET and CSF MTBR-tau243 comparisons validate increased tau aggregation in females.European journal of nuclear medicine and molecular imaging · 2026Article
- Refining our understanding of sleep impairment and connection to Alzheimer's disease in preclinical models.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sleep complaints and genetic risk of Alzheimer's disease in older women: associations with memory and tau deposition.The journal of prevention of Alzheimer's disease · 2026Article
- The Neurology of Menopause.Current neurology and neuroscience reports · 2026Review
- Sex differences in disease burden in China from 1990 to 2023 triangulating GBD and CHARLS.iScience · 2026Article
424 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
introductionPrecision medicine methodologies and approaches have advanced our understanding of the clinical presentation, development, progression, and management of Alzheimer's disease (AD) dementia. However, sex and gender have not yet been adequately integrated into many of these approaches.
methodsThe Society for Women's Health Research Interdisciplinary Network on AD, comprised of an expert panel of scientists and clinicians, reviewed ongoing and published research related to sex and gender differences in AD.
resultsThe current review is a result of this Network's efforts and aims to: (1) highlight the current state-of-the-science in the AD field on sex and gender differences; (2) address knowledge gaps in assessing sex and gender differences; and (3) discuss 12 priority areas that merit further research. DISCUSSION: The exclusion of sex and gender has impeded faster advancement in the detection, treatment, and care of AD across the clinical spectrum. Greater attention to these differences will improve outcomes for both sexes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.