Evidence map›Paper›PMID 29907144›Full record

ArticleBMC cancer2018

A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk.

Qin Xiao, Lianzhou Chen, Haiqing Luo, Hongmei Li, Qingming Kong, Fei Jiao, Shifeng Pang, Ming Zhang, Feifei Lan, Wenguo Fan and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Pan-Cancer Analysis Identifies CHD5 as a Potential Biomarker for Glioma.International journal of molecular sciences · 2022
    Article
  2. Pathway analysis of smoking-induced changes in buccal mucosal gene expression.The Egyptian journal of medical human genetics · 2022
    Article
  3. GWAS in cancer: progress and challenges.Molecular genetics and genomics : MGG · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Qin XiaoGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China.
Lianzhou ChenDigestive System Tumor Tissue Bank, Center of Surgery Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Haiqing LuoGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China.
Hongmei LiGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China.
Qingming KongImmunity and Biochemical Research Lab, Zhejiang Academy of Medical Sciences, Hangzhou, China.
Fei JiaoDepartment of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, China.
Shifeng PangGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China.
Ming ZhangDepartment of Gastroenterology, Zibo Central Hospital, Zibo, China.
Feifei LanForensic Identification Institute, Guangdong Women and Children Hospital, Guangzhou, China.
Wenguo FanGuanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.
Hui LuoGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China. luohui@gdmu.edu.cn.
Tao TaoDepartment of Gastroenterology, Zibo Central Hospital, Zibo, China. tao_tao79@163.com.
Xiao ZhuGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China. bioxzhu@yahoo.com.
Guangdong Medical College · CNCentral Hospital of Zibo · CNBinzhou University · CNGuangdong Province Women and Children Hospital · CNHospital of Stomatology, Sun Yat-sen UniversityPeking University Shenzhen Hospital · CNSun Yat-sen University · CNZhejiang Academy of Medical Sciences · CN

Funding

Guangdong Provincial Science and Technology Programs 2014A020212653Guangdong Provincial Science and Technology Programs 2016A050503046Science and Technology Research Project in Dongguan City 2014108101048The Public Service Platform of South China Sea for R&D Marine Biomedicine Resources 2018008
6 · The paper itself

Abstract

backgroundCHD5 is a conventional tumour-suppressing gene in many tumours. The aim of this study was to determine whether CHD5 variants contribute to the risk of hepatocellular carcinoma (HCC).

methodsGene variants were identified using next-generation sequencing targeted on referenced mutations followed by TaqMan genotyping in two case-control studies.

resultsWe discovered a rare variant (haplotype AG) in CHD5 (rs12564469-rs9434711) that was markedly associated with the risk of HCC in a Chinese population. A logistical regression model and permutation test confirmed the association. Indeed, the association quality increased in a gene dose-dependent manner as the number of samples increased. In the stratified analysis, this haplotype risk effect was statistically significant in a subgroup of alcohol drinkers. The false-positive report probability and multifactor dimensionality reduction further supported the finding.

conclusionsOur results suggest that the rare CHD5 gene haplotype and alcohol intake contribute to the risk of HCC. Our findings can be valuable to researchers of cancer precision medicine looking to improve diagnosis and treatment of HCC.

Indexed as

AdultAgedAlcohol DrinkingAsian PeopleCarcinoma, HepatocellularCase-Control StudiesDNA HelicasesFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHaplotypesHumansLiver NeoplasmsMaleMiddle AgedNerve Tissue ProteinsCHD5 protein, humanDNA HelicasesNerve Tissue ProteinsAlcohol intakeCHD5Gene haplotypeHepatocellular carcinomaRisk

Identifiers

PMID29907144
PMCPMC6003142
OpenAlexW2808248320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.