ArticleDevelopmental cognitive neuroscience2018
Mechanical properties of the in vivo adolescent human brain.
Article in Developmental cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 71 citations in OpenAlex.
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- Neuromechanobiology: Bridging Mechanobiology and Neuroscience Through Evidence and Open Questions.Cells · 2026Review
- Dynamic Hydrogel-Based Strategy for Traumatic Brain Injury Modeling and Therapy.CNS neuroscience & therapeutics · 2025Review
- MRI-based whole-brain elastography and volumetric measurements to predict brain age.Biology methods & protocols · 2025Article
- Characterization of intracranial compliance in healthy subjects using a noninvasive method - results from a multicenter prospective observational study.Journal of clinical monitoring and computing · 2024Observational
- The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Acute effects of high-intensity exercise on brain mechanical properties and cognitive function.Brain imaging and behavior · 2024Article
- Post-mortem changes of anisotropic mechanical properties in the porcine brain assessed by MR elastography.Brain multiphysics · 2024Article
- Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential.CNS neuroscience & therapeutics · 2024Review
- Magnetic resonance elastography captures a transient benefit of exercise intervention on forebrain stiffness in a rat model of fetal alcohol spectrum disorders.Alcohol, clinical & experimental research · 2024Article
- Simultaneous High-Frame-Rate Acoustic Plane-Wave and Optical Imaging of Intracranial Cavitation in Polyacrylamide Brain Phantoms during Blunt Force Impact.Bioengineering (Basel, Switzerland) · 2024Article
- The contributions of relative brain viscosity to brain function and health.Brain communications · 2024Review
- Clinical application of magnetic resonance elastography in pediatric neurological disorders.Pediatric radiology · 2023Review
- Mechanical stiffness and anisotropy measured by MRE during brain development in the minipig.NeuroImage · 2023Article
- Characterization of material properties and deformation in the ANGUS phantom during mild head impacts using MRI.Journal of the mechanical behavior of biomedical materials · 2023Article
- Hippocampus of the APPFrontiers in aging neuroscience · 2023Article
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Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Viscoelastic mechanical properties of the in vivo human brain, measured noninvasively with magnetic resonance elastography (MRE), have recently been shown to be affected by aging and neurological disease, as well as relate to performance on cognitive tasks in adults. The demonstrated sensitivity of brain mechanical properties to neural tissue integrity make them an attractive target for examining the developing brain; however, to date, MRE studies on children are lacking. In this work, we characterized global and regional brain stiffness and damping ratio in a sample of 40 adolescents aged 12-14 years, including the lobes of the cerebrum and subcortical gray matter structures. We also compared the properties of the adolescent brain to the healthy adult brain. Temporal and parietal cerebral lobes were softer in adolescents compared to adults. We found that of subcortical gray matter structures, the caudate and the putamen were significantly stiffer in adolescents, and that the hippocampus and amygdala were significantly less stiff than all other subcortical structures. This study provides the first detailed characterization of adolescent brain viscoelasticity and provides baseline data to be used in studying development and pathophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.