ArticleBrain, behavior, and immunity2018
TSPO expression and brain structure in the psychosis spectrum.
Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Neurofilament light-chain (NfL) and 18 kDa translocator protein in early psychosis and its putative high-risk.Brain, behavior, & immunity - health · 2024Article
- Microglia-neuron interactions in schizophrenia.Frontiers in cellular neuroscience · 2024Review
- A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([Frontiers in medicine · 2023Article
- Microglia imaging in methamphetamine use disorder: a positron emission tomography study with the 18 kDa translocator protein radioligand [F-18]FEPPA.Addiction biology · 2021Article
- Effects of Antipsychotic Drugs: Cross Talk Between the Nervous and Innate Immune System.CNS drugs · 2020Review
- Selective Review of Neuroimaging Findings in Youth at Clinical High Risk for Psychosis: On the Path to Biomarkers for Conversion.Frontiers in psychiatry · 2020Review
- Small animal imaging presents an opportunity for improving translational research in biological psychiatry.Journal of psychiatry & neuroscience : JPNArticle
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10 authors at 3 institutions in 1 country.
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Abstract
Psychosis is associated with abnormal structural changes in the brain including decreased regional brain volumes and abnormal brain morphology. However, the underlying causes of these structural abnormalities are less understood. The immune system, including microglial activation, has been implicated in the pathophysiology of psychosis. Although previous studies have suggested a connection between peripheral proinflammatory cytokines and structural brain abnormalities in schizophrenia, no in-vivo studies have investigated whether microglial activation is also linked to brain structure alterations previously observed in schizophrenia and its putative prodrome. In this study, we investigated the link between mitochondrial 18 kDa translocator protein (TSPO) and structural brain characteristics (i.e. regional brain volume, cortical thickness, and hippocampal shape) in key brain regions such as dorsolateral prefrontal cortex and hippocampus of a large group of participants (N = 90) including individuals at clinical high risk (CHR) for psychosis, first-episode psychosis (mostly antipsychotic-naïve) patients, and healthy volunteers. The participants underwent structural brain MRI scan and [
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